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Impact of dietary n-3 polyunsaturated fatty acids on cognition, motor skills and hippocampal neurogenesis in developing C57BL/6J mice.
Janssen, Carola I F; Zerbi, Valerio; Mutsaers, Martina P C; de Jong, Bas S W; Wiesmann, Maximilian; Arnoldussen, Ilse A C; Geenen, Bram; Heerschap, Arend; Muskiet, Frits A J; Jouni, Zeina E; van Tol, Eric A F; Gross, Gabriele; Homberg, Judith R; Berg, Brian M; Kiliaan, Amanda J.
Afiliación
  • Janssen CI; Department of Anatomy, Donders Institute for Brain, Cognition, and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
  • Zerbi V; Department of Anatomy, Donders Institute for Brain, Cognition, and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
  • Mutsaers MP; Department of Anatomy, Donders Institute for Brain, Cognition, and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
  • de Jong BS; Department of Anatomy, Donders Institute for Brain, Cognition, and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
  • Wiesmann M; Department of Anatomy, Donders Institute for Brain, Cognition, and Behaviour, Radboud university medical center, Nijmegen, The Netherlands; Department of Geriatrics, Donders Institute for Brain, Cognition, and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
  • Arnoldussen IA; Department of Anatomy, Donders Institute for Brain, Cognition, and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
  • Geenen B; Department of Anatomy, Donders Institute for Brain, Cognition, and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
  • Heerschap A; Department of Radiology, Donders Institute for Brain, Cognition, and Behaviour, Radboud university medical centerr, Nijmegen, The Netherlands.
  • Muskiet FA; Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands.
  • Jouni ZE; Mead Johnson Pediatric Nutrition Institute, Nijmegen/Evansville, The Netherlands/IN, USA.
  • van Tol EA; Mead Johnson Pediatric Nutrition Institute, Nijmegen/Evansville, The Netherlands/IN, USA.
  • Gross G; Mead Johnson Pediatric Nutrition Institute, Nijmegen/Evansville, The Netherlands/IN, USA.
  • Homberg JR; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
  • Berg BM; Mead Johnson Pediatric Nutrition Institute, Nijmegen/Evansville, The Netherlands/IN, USA.
  • Kiliaan AJ; Department of Anatomy, Donders Institute for Brain, Cognition, and Behaviour, Radboud university medical center, Nijmegen, The Netherlands. Electronic address: Amanda.Kiliaan@radboudumc.nl.
J Nutr Biochem ; 26(1): 24-35, 2015 Jan.
Article en En | MEDLINE | ID: mdl-25444517
Maternal intake of omega-3 polyunsaturated fatty acids (n-3 PUFA) is critical during perinatal development of the brain. Docosahexaenoic acid (DHA) is the most abundant n-3 PUFA in the brain and influences neuronal membrane function and neuroprotection. The present study aims to assess the effect of dietary n-3 PUFA availability during the gestational and postnatal period on cognition, brain metabolism and neurohistology in C57BL/6J mice. Female wild-type C57BL/6J mice at day 0 of gestation were randomly assigned to either an n-3 PUFA deficient diet (0.05% of total fatty acids) or an n-3 PUFA adequate diet (3.83% of total fatty acids) containing preformed DHA and its precursor α-linolenic acid. Male offspring remained on diet and performed cognitive tests during puberty and adulthood. In adulthood, animals underwent (31)P magnetic resonance spectroscopy to assess brain energy metabolites. Thereafter, biochemical and immunohistochemical analyses were performed assessing inflammation, neurogenesis and synaptic plasticity. Compared to the n-3 PUFA deficient group, pubertal n-3 PUFA adequate fed mice demonstrated increased motor coordination. Adult n-3 PUFA adequate fed mice exhibited increased exploratory behavior, sensorimotor integration and spatial memory, while neurogenesis in the hippocampus was decreased. Selected brain regions of n-3 PUFA adequate fed mice contained significantly lower levels of arachidonic acid and higher levels of DHA and dihomo-γ-linolenic acid. Our data suggest that dietary n-3 PUFA can modify neural maturation and enhance brain functioning in healthy C57BL/6J mice. This indicates that availability of n-3 PUFA in infant diet during early development may have a significant impact on brain development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Grasos Omega-3 / Cognición / Neurogénesis / Hipocampo / Destreza Motora Límite: Animals Idioma: En Revista: J Nutr Biochem Asunto de la revista: BIOQUIMICA / CIENCIAS DA NUTRICAO Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Grasos Omega-3 / Cognición / Neurogénesis / Hipocampo / Destreza Motora Límite: Animals Idioma: En Revista: J Nutr Biochem Asunto de la revista: BIOQUIMICA / CIENCIAS DA NUTRICAO Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos