Synthesis and structure­activity relationships of small molecule  inhibitors of the simian virus 40 T antigen oncoprotein,  an anti-polyomaviral target.

Ireland, Alex W; Gobillot, Theodore A; Gupta, Tushar; Seguin, Sandlin P; Liang, Mary; Resnick, Lynn; Goldberg, Margot T; Manos-Turvey, Alexandra; Pipas, James M; Wipf, Peter; Brodsky, Jeffrey L

Synthesis and structureactivity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target.

Ireland, Alex W; Gobillot, Theodore A; Gupta, Tushar; Seguin, Sandlin P; Liang, Mary; Resnick, Lynn; Goldberg, Margot T; Manos-Turvey, Alexandra; Pipas, James M; Wipf, Peter; Brodsky, Jeffrey L.

Afiliación

Ireland AW; Department of Biological Science, University of Pittsburgh, Pittsburgh, PA 15260.
Gobillot TA; Department of Biological Science, University of Pittsburgh, Pittsburgh, PA 15260.
Gupta T; Department of Biological Science, University of Pittsburgh, Pittsburgh, PA 15260.
Seguin SP; Department of Biological Science, University of Pittsburgh, Pittsburgh, PA 15260.
Liang M; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260.
Resnick L; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260.
Goldberg MT; Department of Biological Science, University of Pittsburgh, Pittsburgh, PA 15260.
Manos-Turvey A; Department of Biological Science, University of Pittsburgh, Pittsburgh, PA 15260.
Pipas JM; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260.
Wipf P; Department of Biological Science, University of Pittsburgh, Pittsburgh, PA 15260.
Brodsky JL; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260.

Bioorg Med Chem ; 22(22): 6490-6502, 2014 Nov 15.

Article en En | MEDLINE | ID: mdl-25440730

Asunto(s)

Antígenos Virales de Tumores/química; Antivirales/síntesis química; Virus 40 de los Simios/metabolismo; Bibliotecas de Moléculas Pequeñas/química; Antígenos Virales de Tumores/metabolismo; Antivirales/farmacología; Antivirales/toxicidad; Supervivencia Celular/efectos de los fármacos; Células HEK293; Humanos; Peptoides/química; Poliomavirus/efectos de los fármacos; Unión Proteica; Pirimidinonas/química; Bibliotecas de Moléculas Pequeñas/síntesis química; Bibliotecas de Moléculas Pequeñas/farmacología; Relación Estructura-Actividad; Replicación Viral/efectos de los fármacos

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Virus 40 de los Simios / Bibliotecas de Moléculas Pequeñas / Antígenos Virales de Tumores Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido

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