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Development, validation and influence factor analysis of a near-infrared method for the molecular weight determination of xanthan gum.
Song, Zhigang; Ling, Peixue; Zang, Hengchang; Li, Lian; Wang, Jinfeng; Jin, Yan; Shao, Huarong; Zhu, Xiqiang; Liu, Fei; Wang, Fengshan.
Afiliación
  • Song Z; School of Pharmaceutical Sciences and National Glycoengineering Research Center, Shandong University, Jinan 250012, China; Post-doctoral Scientific Research Workstation, Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China.
  • Ling P; School of Pharmaceutical Sciences and National Glycoengineering Research Center, Shandong University, Jinan 250012, China; Post-doctoral Scientific Research Workstation, Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China. Electronic address: lpx@sdfmg.com.
  • Zang H; School of Pharmaceutical Sciences and National Glycoengineering Research Center, Shandong University, Jinan 250012, China.
  • Li L; School of Pharmaceutical Sciences and National Glycoengineering Research Center, Shandong University, Jinan 250012, China.
  • Wang J; School of Pharmaceutical Sciences and National Glycoengineering Research Center, Shandong University, Jinan 250012, China.
  • Jin Y; Post-doctoral Scientific Research Workstation, Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China.
  • Shao H; School of Pharmaceutical Sciences and National Glycoengineering Research Center, Shandong University, Jinan 250012, China; Post-doctoral Scientific Research Workstation, Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China.
  • Zhu X; Post-doctoral Scientific Research Workstation, Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China.
  • Liu F; Post-doctoral Scientific Research Workstation, Shandong Academy of Pharmaceutical Sciences, Jinan 250101, China.
  • Wang F; School of Pharmaceutical Sciences and National Glycoengineering Research Center, Shandong University, Jinan 250012, China. Electronic address: fswang@sdu.edu.cn.
Carbohydr Polym ; 115: 582-8, 2015 Jan 22.
Article en En | MEDLINE | ID: mdl-25439935
A practical molecular weight determination model of xanthan gum (XG), based on near-infrared (NIR) spectroscopy, was built in this study. Two sample measurement modules, integrating sphere module and fiber-optic probe module, were compared, and the best partial least square (PLS) regression model was based on fiber-optic probe module. The values of coefficient of determination in calibration (R(2)c), coefficient of determination in prediction (R(2)p), residual predictive deviation (RPD) and root mean square error of prediction (RMSEP) were 0.967, 0.975, 6.028 and 0.250×10(6)Da, respectively. The molecular weight range, linearity, accuracy and precision of the established method were also validated. Furthermore, influence factors on this method were discussed in order to establish an appropriate measurement protocol. Results showed that the proposed NIR method may be suitable for practical applications in manufacturing plants and probably be accepted as a good alternative approach for fast determination of molecular weight of XG in production process.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Prognostic_studies Idioma: En Revista: Carbohydr Polym Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Prognostic_studies Idioma: En Revista: Carbohydr Polym Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido