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Non transferrin bound iron (NTBI) in acute leukemias throughout conventional intensive chemotherapy: kinetics of its appearance and potential predictive role in infectious complications.
Belotti, Angelo; Duca, Lorena; Borin, Lorenza; Realini, Silvia; Renso, Rossella; Parma, Matteo; Pioltelli, Pietro; Pogliani, Enrico; Cappellini, Maria Domenica.
Afiliación
  • Belotti A; Department of Haematology, Ospedale San Gerardo, University of Milano Bicocca, Via Pergolesi 33, 20900 Monza, Italy. Electronic address: ange.belotti@gmail.com.
  • Duca L; Department of Medicine and Medical Specialities, "Ca' Granda" Foundation IRCCS, University of Milan, Via F. Sforza 35, 20122 Milano, Italy. Electronic address: lorena.duca@guest.unimi.it.
  • Borin L; Department of Haematology, Ospedale San Gerardo, University of Milano Bicocca, Via Pergolesi 33, 20900 Monza, Italy. Electronic address: l.borin@hsgerardo.org.
  • Realini S; Department of Haematology, Ospedale San Gerardo, University of Milano Bicocca, Via Pergolesi 33, 20900 Monza, Italy. Electronic address: silvia.realini@hotmail.it.
  • Renso R; Department of Haematology, Ospedale San Gerardo, University of Milano Bicocca, Via Pergolesi 33, 20900 Monza, Italy. Electronic address: rossella.renso@gmail.com.
  • Parma M; Department of Haematology, Ospedale San Gerardo, University of Milano Bicocca, Via Pergolesi 33, 20900 Monza, Italy. Electronic address: m.parma@hsgerardo.org.
  • Pioltelli P; Department of Haematology, Ospedale San Gerardo, University of Milano Bicocca, Via Pergolesi 33, 20900 Monza, Italy. Electronic address: p.pioltelli@hsgerardo.org.
  • Pogliani E; Department of Haematology, Ospedale San Gerardo, University of Milano Bicocca, Via Pergolesi 33, 20900 Monza, Italy. Electronic address: enrico.pogliani@unimib.it.
  • Cappellini MD; Department of Medicine and Medical Specialities, "Ca' Granda" Foundation IRCCS, University of Milan, Via F. Sforza 35, 20122 Milano, Italy. Electronic address: maria.cappellini@unimi.it.
Leuk Res ; 39(1): 88-91, 2015 Jan.
Article en En | MEDLINE | ID: mdl-25435028
We analyzed appearance of non transferrin bound iron (NTBI) in 30 transplant eligible patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) during conventional chemotherapy treatment program and evaluated possible relationship with transfusional body iron intake, iron parameters and clinical complications. For each course, serum samples for NTBI detection were taken prior to chemotherapy, during treatment and during subsequent bone marrow myelosuppression: NTBI was assessed by HPLC. Appearance of NTBI was observed from the start of induction treatment and was still detectable during bone marrow myelosuppression; the recovery of the bone marrow function coincided with the disappearance of NTBI. This kinetic was observed in all subsequent high doses chemotherapy courses, independently from confounding variables such as transfusional iron intake and transferrin saturation. NTBI seems to be a consequence of chemotherapy induced lysis of bone marrow cells and, partly, of hepatocytes after cytotoxic injury. The subsequent persistence of NTBI throughout bone marrow myelosuppression is related to the transient suspension of erythropoietic activity. Moreover, NTBI levels >2µM at the beginning of iatrogenic myelosuppression were associated with higher risk of sepsis caused by Gram negative Bacilli (RR 2.571), also compared with other infectious complications (RR 1.954).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Leucemia-Linfoma Linfoblástico de Células Precursoras / Hierro Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Leuk Res Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Leucemia-Linfoma Linfoblástico de Células Precursoras / Hierro Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Leuk Res Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido