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Comparison of paclitaxel and everolimus-eluting stents in ST-segment elevation myocardial infarction and influence of thrombectomy on outcomes. ESTROFA-IM study.
de la Torre Hernández, José M; Alfonso, Fernando; Martin Yuste, Victoria; Sánchez Recalde, Angel; Jimenez Navarro, Manuel F; Pérez de Prado, Armando; Hernández, Felipe; Abdul-Jawad Altisent, Omar; Roura, Gerard; García Camarero, Tamara; Elizaga, Jaime; Calviño, Ramón; Moreu, Jose; Bosa, Francisco; Jimenez Mazuecos, Jesús; Ruiz-Arroyo, José R; Garcia Del Blanco, Bruno; Rumoso, José R.
Afiliación
  • de la Torre Hernández JM; Servicio de Cardiología, Hospital Marqués de Valdecilla, Santander, Cantabria, Spain. Electronic address: he1thj@humv.es.
  • Alfonso F; Servicio de Cardiología, Hospital Clínico San Carlos, Madrid, Spain.
  • Martin Yuste V; Servicio de Cardiología, Hospital Clínic, Barcelona, Spain.
  • Sánchez Recalde A; Servicio de Cardiología, Hospital La Paz, Madrid, Spain.
  • Jimenez Navarro MF; Servicio de Cardiología, Hospital Virgen de la Victoria, Malaga, Spain.
  • Pérez de Prado A; Servicio de Cardiología, Hospital de León, León, Spain.
  • Hernández F; Servicio de Cardiología, Hospital 12 de Octubre, Madrid, Spain.
  • Abdul-Jawad Altisent O; Servicio de Cardiología, Hospital Vall d'Hebron, Barcelona, Spain.
  • Roura G; Servicio de Cardiología, Hospital de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
  • García Camarero T; Servicio de Cardiología, Hospital Marqués de Valdecilla, Santander, Cantabria, Spain.
  • Elizaga J; Servicio de Cardiología, Hospital Gregorio Marañon, Madrid, Spain.
  • Calviño R; Servicio de Cardiología, Hospital de la Coruña, CHUAC, La Coruña, Spain.
  • Moreu J; Servicio de Cardiología, Hospital Virgen de la Salud, Toledo, Spain.
  • Bosa F; Servicio de Cardiología, Hospital Clínico de Tenerife, Santa Cruz de Tenerife, Spain.
  • Jimenez Mazuecos J; Servicio de Cardiología, Hospital de Albacete, Albacete, Spain.
  • Ruiz-Arroyo JR; Servicio de Cardiología, Hospital Clínico Lozano Blesa, Zaragoza, Spain.
  • Garcia Del Blanco B; Servicio de Cardiología, Hospital Vall d'Hebron, Barcelona, Spain.
  • Rumoso JR; Servicio de Cardiología, Hospital de Galdakao, Bilbao, Vizcaya, Spain.
Rev Esp Cardiol (Engl Ed) ; 67(12): 999-1006, 2014 Dec.
Article en En | MEDLINE | ID: mdl-25432710
INTRODUCTION AND OBJECTIVES: We sought to compare the long-term clinical outcome of with ST-segment elevation myocardial infarction treated with paclitaxel-eluting stents or everolimus-eluting stents and the influence of thrombectomy on outcomes. METHODS: The ESTROFA-IM is a multicenter retrospective registry collecting consecutive patients with infarction treated with these stents in 16 centers. Propensity-score matching was performed to select comparable stent groups and comparable groups with and without thrombectomy. RESULTS: After matching patients, 350 treated with everolimus-eluting stents and 350 with paclitaxel-eluting stents were included in the analysis. The clinical and angiographic characteristics were comparable in both groups. The 2-year incidence of death, infarction, and target lesion revascularization was 14.9% for paclitaxel-eluting stents and 11.5% for everolimus-eluting stents (P = .04) and the incidence of definite/probable thrombosis 4.3% and 1.4%, respectively (P = .01). The use of paclitaxel-eluting was an independent predictor for events (hazard ratio = 2.44, 95% confidence interval, 1.28-4.65; P = .006). The benefit of everolimus-eluting stents over paclitaxel-eluting stents regarding stent thrombosis was more evident in the nonthrombectomy subgroup (5.4% vs 1.4%; P = .01). A significant interaction was found in the subgroups with and without thombectomy in the comparison between paclitaxel-eluting stents and everolimus-eluting stents for the end-point of stent thrombosis (P = .039). CONCLUSIONS: The results of this multicenter registry suggest better clinical outcomes with the everolimus-eluting stents in ST-segment elevation myocardial infarction. The lower risk of thrombosis with these stents could be more relevant in the absence of thrombectomy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prótesis Vascular / Trombectomía / Paclitaxel / Stents Liberadores de Fármacos / Everolimus / Infarto del Miocardio Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Rev Esp Cardiol (Engl Ed) Año: 2014 Tipo del documento: Article Pais de publicación: España
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prótesis Vascular / Trombectomía / Paclitaxel / Stents Liberadores de Fármacos / Everolimus / Infarto del Miocardio Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Rev Esp Cardiol (Engl Ed) Año: 2014 Tipo del documento: Article Pais de publicación: España