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CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.
Chipumuro, Edmond; Marco, Eugenio; Christensen, Camilla L; Kwiatkowski, Nicholas; Zhang, Tinghu; Hatheway, Clark M; Abraham, Brian J; Sharma, Bandana; Yeung, Caleb; Altabef, Abigail; Perez-Atayde, Antonio; Wong, Kwok-Kin; Yuan, Guo-Cheng; Gray, Nathanael S; Young, Richard A; George, Rani E.
Afiliación
  • Chipumuro E; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA 02215, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  • Marco E; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard School of Public Health, Boston, MA 02115, USA.
  • Christensen CL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Kwiatkowski N; Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Zhang T; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  • Hatheway CM; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA 02215, USA.
  • Abraham BJ; Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Sharma B; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA 02215, USA.
  • Yeung C; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA 02215, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  • Altabef A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Perez-Atayde A; Department of Pathology, Boston Children's Hospital, MA 02115, USA.
  • Wong KK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  • Yuan GC; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard School of Public Health, Boston, MA 02115, USA.
  • Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
  • Young RA; Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • George RE; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA 02215, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: rani_george@dfci.harvard.edu.
Cell ; 159(5): 1126-1139, 2014 Nov 20.
Article en En | MEDLINE | ID: mdl-25416950
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenilendiaminas / Pirimidinas / Proteínas Nucleares / Proteínas Oncogénicas / Quinasas Ciclina-Dependientes / Inhibidores de Proteínas Quinasas / Modelos Animales de Enfermedad / Neuroblastoma Límite: Animals / Humans Idioma: En Revista: Cell Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenilendiaminas / Pirimidinas / Proteínas Nucleares / Proteínas Oncogénicas / Quinasas Ciclina-Dependientes / Inhibidores de Proteínas Quinasas / Modelos Animales de Enfermedad / Neuroblastoma Límite: Animals / Humans Idioma: En Revista: Cell Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos