Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients.

Berg, Anna; Hoivik, Erling A; Mjøs, Siv; Holst, Frederik; Werner, Henrica M J; Tangen, Ingvild L; Taylor-Weiner, Amaro; Gibson, William J; Kusonmano, Kanthida; Wik, Elisabeth; Trovik, Jone; Halle, Mari K; Øyan, Anne M; Kalland, Karl-Henning; Cherniack, Andrew D; Beroukhim, Rameen; Stefansson, Ingunn; Mills, Gordon B; Krakstad, Camilla; Salvesen, Helga B

Berg, Anna; Hoivik, Erling A; Mjøs, Siv; Holst, Frederik; Werner, Henrica M J; Tangen, Ingvild L; Taylor-Weiner, Amaro; Gibson, William J; Kusonmano, Kanthida; Wik, Elisabeth; Trovik, Jone; Halle, Mari K; Øyan, Anne M; Kalland, Karl-Henning; Cherniack, Andrew D; Beroukhim, Rameen; Stefansson, Ingunn; Mills, Gordon B; Krakstad, Camilla; Salvesen, Helga B.

Afiliación

Berg A; Department of Clinical Science, Center for Cancer Biomarkers, University of Bergen, Norway.
Hoivik EA; Department of Gynecology and Obstetrics, Haukeland University Hospital, Norway.
Mjøs S; Department of Clinical Science, Center for Cancer Biomarkers, University of Bergen, Norway.
Holst F; Department of Gynecology and Obstetrics, Haukeland University Hospital, Norway.
Werner HM; Department of Clinical Science, Center for Cancer Biomarkers, University of Bergen, Norway.
Tangen IL; Department of Gynecology and Obstetrics, Haukeland University Hospital, Norway.
Taylor-Weiner A; Department of Clinical Science, Center for Cancer Biomarkers, University of Bergen, Norway.
Gibson WJ; Department of Gynecology and Obstetrics, Haukeland University Hospital, Norway.
Kusonmano K; Department of Clinical Science, Center for Cancer Biomarkers, University of Bergen, Norway.
Wik E; Department of Gynecology and Obstetrics, Haukeland University Hospital, Norway.
Trovik J; Department of Clinical Science, Center for Cancer Biomarkers, University of Bergen, Norway.
Halle MK; Department of Gynecology and Obstetrics, Haukeland University Hospital, Norway.
Øyan AM; The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.
Kalland KH; Department of Cancer Biology and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.
Cherniack AD; Harvard Medical School, Boston, Massachusetts, United States of America.
Beroukhim R; The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.
Stefansson I; Department of Cancer Biology and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.
Mills GB; Harvard Medical School, Boston, Massachusetts, United States of America.
Krakstad C; Department of Clinical Science, Center for Cancer Biomarkers, University of Bergen, Norway.
Salvesen HB; Department of Gynecology and Obstetrics, Haukeland University Hospital, Norway.

Oncotarget ; 6(2): 1327-39, 2015 Jan 20.

Article en En | MEDLINE | ID: mdl-25415225

Asunto(s)

Neoplasias Endometriales/genética; Neoplasias Endometriales/metabolismo; Perfilación de la Expresión Génica/métodos; Obesidad/complicaciones; Proteómica/métodos; Biomarcadores de Tumor/genética; Biomarcadores de Tumor/metabolismo; Índice de Masa Corporal; Fosfatidilinositol 3-Quinasa Clase I; Estudios de Cohortes; Neoplasias Endometriales/diagnóstico; Exoma/genética; Femenino; Humanos; Inmunohistoquímica; Hibridación Fluorescente in Situ; Mutación; Metástasis de la Neoplasia; Análisis de Secuencia por Matrices de Oligonucleótidos; Fosfohidrolasa PTEN/genética; Fosfohidrolasa PTEN/metabolismo; Fosfatidilinositol 3-Quinasas/genética; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas/genética; Proteínas Proto-Oncogénicas/metabolismo; Proteínas Proto-Oncogénicas p21(ras); ARN Mensajero/genética; ARN Mensajero/metabolismo; Análisis de Secuencia de ADN; Proteínas ras/genética; Proteínas ras/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Endometriales / Perfilación de la Expresión Génica / Proteómica / Obesidad Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Oncotarget Año: 2015 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Estados Unidos

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