Higher 17α-hydroxyprogesterone levels aggravated the severity of male adolescent acne in Northeast China.
Dermatology
; 229(4): 359-62, 2014.
Article
en En
| MEDLINE
| ID: mdl-25413081
BACKGROUND: The relationship between serum hormone levels and adolescent acne is not fully clarified. OBJECTIVE: To determine the relationship between levels of androstenedione, dehydroepiandrosterone sulfate (DHEA-S), testosterone, estradiol and 17α-hydroxyprogesterone (17-OHP) with adolescent acne in Northeast China. METHODS: A transversal study included 242 acne cases and 188 controls. All data were analyzed using SPSS version 17.0. RESULTS: Androstenedione and testosterone levels were significantly higher (p < 0.0001) in the cases than in the control group. In males, the difference in 17-OHP levels was statistically significant (p < 0.0001), as well as between mild and severe acne cases (p = 0.002). The estradiol level was significantly different (p < 0.0001) between cases and controls in females. CONCLUSION: Higher androstenedione and testosterone levels are significant risk factors in the occurrence of adolescent acne. A higher 17-OHP level aggravates the severity of male adolescent acne, while a higher estradiol level protects females against the onset of adolescent acne.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Progesterona
/
Testosterona
/
Acné Vulgar
/
Sulfato de Deshidroepiandrosterona
/
Estradiol
/
Androstenodiona
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Dermatology
Asunto de la revista:
DERMATOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Suiza