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Whole-body and hepatic insulin resistance in obese children.
Ibarra-Reynoso, Lorena del Rocío; Pisarchyk, Liudmila; Pérez-Luque, Elva Leticia; Garay-Sevilla, Ma Eugenia; Malacara, Juan Manuel.
Afiliación
  • Ibarra-Reynoso Ldel R; Department of Medical Sciences, University of Guanajuato, Campus León, 20 de Enero 929, León Guanajuato, México.
  • Pisarchyk L; Department of Medical Sciences, University of Guanajuato, Campus León, 20 de Enero 929, León Guanajuato, México.
  • Pérez-Luque EL; Department of Medical Sciences, University of Guanajuato, Campus León, 20 de Enero 929, León Guanajuato, México.
  • Garay-Sevilla ME; Department of Medical Sciences, University of Guanajuato, Campus León, 20 de Enero 929, León Guanajuato, México.
  • Malacara JM; Department of Medical Sciences, University of Guanajuato, Campus León, 20 de Enero 929, León Guanajuato, México.
PLoS One ; 9(11): e113576, 2014.
Article en En | MEDLINE | ID: mdl-25411786
BACKGROUND: Insulin resistance may be assessed as whole body or hepatic. OBJECTIVE: To study factors associated with both types of insulin resistance. METHODS: Cross-sectional study of 182 obese children. Somatometric measurements were registered, and the following three adiposity indexes were compared: BMI, waist-to-height ratio and visceral adiposity. Whole-body insulin resistance was evaluated using HOMA-IR, with 2.5 as the cut-off point. Hepatic insulin resistance was considered for IGFBP-1 level quartiles 1 to 3 (<6.67 ng/ml). We determined metabolite and hormone levels and performed a liver ultrasound. RESULTS: The majority, 73.1%, of obese children had whole-body insulin resistance and hepatic insulin resistance, while 7% did not have either type. HOMA-IR was negatively associated with IGFBP-1 and positively associated with BMI, triglycerides, leptin and mother's BMI. Girls had increased HOMA-IR. IGFBP-1 was negatively associated with waist-to-height ratio, age, leptin, HOMA-IR and IGF-I. We did not find HOMA-IR or IGFBP-1 associated with fatty liver. CONCLUSION: In school-aged children, BMI is the best metric to predict whole-body insulin resistance, and waist-to-height ratio is the best predictor of hepatic insulin resistance, indicating that central obesity is important for hepatic insulin resistance. The reciprocal negative association of IGFBP-1 and HOMA-IR may represent a strong interaction of the physiological processes of both whole-body and hepatic insulin resistance.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Obesidad Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Obesidad Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos