Your browser doesn't support javascript.
loading
Lipoatrophy in children with type 1 diabetes: an increasing incidence?
Kordonouri, Olga; Biester, Torben; Schnell, Kerstin; Hartmann, Reinhard; Tsioli, Christiana; Fath, Maryam; Datz, Nicolin; Danne, Thomas.
Afiliación
  • Kordonouri O; Diabetes Center for Children and Adolescents, Children's Hospital AUF DER BULT, Hannover, Germany kordonouri@hka.de.
  • Biester T; Diabetes Center for Children and Adolescents, Children's Hospital AUF DER BULT, Hannover, Germany.
  • Schnell K; Diabetes Center for Children and Adolescents, Children's Hospital AUF DER BULT, Hannover, Germany.
  • Hartmann R; Diabetes Center for Children and Adolescents, Children's Hospital AUF DER BULT, Hannover, Germany.
  • Tsioli C; Diabetes Center for Children and Adolescents, Children's Hospital AUF DER BULT, Hannover, Germany.
  • Fath M; Diabetes Center for Children and Adolescents, Children's Hospital AUF DER BULT, Hannover, Germany.
  • Datz N; Diabetes Center for Children and Adolescents, Children's Hospital AUF DER BULT, Hannover, Germany.
  • Danne T; Diabetes Center for Children and Adolescents, Children's Hospital AUF DER BULT, Hannover, Germany.
J Diabetes Sci Technol ; 9(2): 206-8, 2015 Mar.
Article en En | MEDLINE | ID: mdl-25411060
The objectives were to evaluate the current prevalence of lipoatrophy at insulin injection sites in young patients with type 1 diabetes. Standardized examination of insulin injection sites in all 678 patients with type 1 diabetes treated in 2013 in our outpatient clinic were conducted. In case of lipoatrophy photo documentation and standardized interview with parents and patients were performed. We identified a total of 16 patients (43.8% male) with lipoatrophy (overall prevalence 2.4%). The current mean age (±SD) of the affected patients was 14.4 ± 3.9 years, age and diabetes duration at onset of lipoatrophy were 11.5 ± 3.8 years and 5.4 ± 3.6 years, respectively. All patients were using analogs at the onset of lipoatrophy. In all, 14 of 16 patients (87.5%) were on insulin pump compared with 52% without lipoatrophy (P = .0018). The use of steel needle and Teflon catheter was equal between the pump patients. Concomitant autoimmune diseases were present in 37.5% of the patients (thyroiditis: n = 3, thyroiditis and celiac disease: n = 2, celiac disease: n = 1) compared with 15.0% in those without lipoatrophy (P = .0128). Lipoatrophy was present in young patients treated with modern insulins and pumps; however, the prevalence was relatively low as expected with the use of modern insulins. Our data may support the hypothesis that a constant mechanical element such as a subcutaneous catheter may trigger the development of lipoatrophy, particularly in those patients with more than 1 autoimmune disease.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 1 / Grasa Subcutánea / Hipoglucemiantes / Insulina Tipo de estudio: Incidence_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Diabetes Sci Technol Asunto de la revista: ENDOCRINOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 1 / Grasa Subcutánea / Hipoglucemiantes / Insulina Tipo de estudio: Incidence_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Diabetes Sci Technol Asunto de la revista: ENDOCRINOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos