[Atopic bronchial asthma as pathology of the membrane-receptor complex]. / Atopicheskaia bronkhial'naia astma kak patologiia membranno-retseptornogo kompleksa.
Vestn Akad Med Nauk SSSR
; (2): 9-14, 1989.
Article
en Ru
| MEDLINE
| ID: mdl-2540595
The pathogenesis of atopic bronchial asthma (ABA) is examined from a membranologic viewpoint, with a methodological approach, postulating membrane-receptor pathology as the key pathogenetic element of the disease, taken as the basis. Major results of the study of the adrenoreactive system are analysed, and pathogenetic significance of the demonstrated paradoxal cell reaction to beta-adreno-antagonist is pointed out. Prospects related to the development of studies of morphofunctional erythrone properties as a new line of research in BA pathogenesis are demonstrated, and erythrocyte qualities applicable as marker of atopia, such as microcytosis and membrane glycoprotein distribution, are identified. Specific pattern of cell membrane response to aldehyde compounds seen in ABA is described. The data obtained are a development of the earlier-postulated hypothesis of ABA-associated dedifferentiation. A notion of ABA as a membrane-receptor disease is proposed.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Asma
/
Glicoproteínas de Membrana
/
Receptores de Superficie Celular
/
Agregación Eritrocitaria
/
Membrana Eritrocítica
/
Lípidos de la Membrana
Límite:
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Vestn Akad Med Nauk SSSR
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Rusia