Protein-based materials in load-bearing tissue-engineering applications.
Regen Med
; 9(5): 687-701, 2014.
Article
en En
| MEDLINE
| ID: mdl-25372082
Proteins such as collagen and elastin are robust molecules that constitute nanocomponents in the hierarchically organized ultrastructures of bone and tendon as well as in some of the soft tissues that have load-bearing functions. In the present paper, the macromolecular structure and function of the proteins are reviewed and the potential of mammalian and non-mammalian proteins in the engineering of load-bearing tissue substitutes are discussed. Chimeric proteins have become an important structural biomaterial source and their potential in tissue engineering is highlighted. Processing of proteins challenge investigators and in this review rapid prototyping and microfabrication are proposed as methods for obtaining precisely defined custom-built tissue engineered structures with intrinsic microarchitecture.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Materiales Biocompatibles
/
Proteínas
/
Ingeniería de Tejidos
Idioma:
En
Revista:
Regen Med
Año:
2014
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Reino Unido