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Breast tumor segmentation in high resolution x-ray phase contrast analyzer based computed tomography.
Brun, E; Grandl, S; Sztrókay-Gaul, A; Barbone, G; Mittone, A; Gasilov, S; Bravin, A; Coan, P.
Afiliación
  • Brun E; European Synchrotron Radiation Facility (ESRF), Grenoble 380000, France and Department of Physics, Ludwig-Maximilians University, Garching 85748, Germany.
  • Grandl S; Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, 81377 Munich, Germany.
  • Sztrókay-Gaul A; Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, 81377 Munich, Germany.
  • Barbone G; Department of Physics, Harvard University, Cambridge, Massachusetts 02138.
  • Mittone A; Department of Physics, Ludwig-Maximilians University, Garching 85748, Germany and Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, 81377 Munich, Germany.
  • Gasilov S; Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, 81377 Munich, Germany.
  • Bravin A; European Synchrotron Radiation Facility (ESRF), Grenoble 380000, France.
  • Coan P; Department of Physics, Ludwig-Maximilians University, Garching 85748, Germany and Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, 81377 Munich, Germany.
Med Phys ; 41(11): 111902, 2014 Nov.
Article en En | MEDLINE | ID: mdl-25370635
PURPOSE: Phase contrast computed tomography has emerged as an imaging method, which is able to outperform present day clinical mammography in breast tumor visualization while maintaining an equivalent average dose. To this day, no segmentation technique takes into account the specificity of the phase contrast signal. In this study, the authors propose a new mathematical framework for human-guided breast tumor segmentation. This method has been applied to high-resolution images of excised human organs, each of several gigabytes. METHODS: The authors present a segmentation procedure based on the viscous watershed transform and demonstrate the efficacy of this method on analyzer based phase contrast images. The segmentation of tumors inside two full human breasts is then shown as an example of this procedure's possible applications. RESULTS: A correct and precise identification of the tumor boundaries was obtained and confirmed by manual contouring performed independently by four experienced radiologists. CONCLUSIONS: The authors demonstrate that applying the watershed viscous transform allows them to perform the segmentation of tumors in high-resolution x-ray analyzer based phase contrast breast computed tomography images. Combining the additional information provided by the segmentation procedure with the already high definition of morphological details and tissue boundaries offered by phase contrast imaging techniques, will represent a valuable multistep procedure to be used in future medical diagnostic applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Procesamiento de Imagen Asistido por Computador / Neoplasias de la Mama / Tomografía Computarizada por Rayos X Tipo de estudio: Guideline Límite: Aged / Aged80 / Female / Humans Idioma: En Revista: Med Phys Año: 2014 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Procesamiento de Imagen Asistido por Computador / Neoplasias de la Mama / Tomografía Computarizada por Rayos X Tipo de estudio: Guideline Límite: Aged / Aged80 / Female / Humans Idioma: En Revista: Med Phys Año: 2014 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos