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Genetic association analyses of fast plasma glucose level in pre-menopausal Chinese women: potential interaction between osteocalcin and oestrogen receptor α.
Xu, Hong; He, Lu-Ling; Xiong, Chao-Peng; Gong, Cheng-Xin; Liu, Chang-Le; Peng, Lu-Lu; Cheng, Ya-Jun; Jiang, Fu-Qing; Tan, Li-Ping; Tang, Lan; Peng, Wei; Tu, Yun-Ming; Yang, Yu-Ping; Luo, Dan; Zou, Lin; Liang, Shang-Dong.
Afiliación
  • Xu H; a Department of Physiology , Jiangxi Medical College of Nanchang University , Nanchang , Jiangxi , PR China .
  • He LL; a Department of Physiology , Jiangxi Medical College of Nanchang University , Nanchang , Jiangxi , PR China .
  • Xiong CP; b Foreign Nursing Class-2013 Grade, Fuzhou Medical College of Nanchang University , Fuzhou , Jiangxi , PR China .
  • Gong CX; c School of Life Science & Technology, China Pharmaceutical University , Nanjing , PR China .
  • Liu CL; a Department of Physiology , Jiangxi Medical College of Nanchang University , Nanchang , Jiangxi , PR China .
  • Peng LL; d Experimental Class-2011 Grade .
  • Cheng YJ; d Experimental Class-2011 Grade .
  • Jiang FQ; e Analysis Class-2011 Grade , and.
  • Tan LP; e Analysis Class-2011 Grade , and.
  • Tang L; f Clinic 6 Class-2012 Grade, Jiangxi Medical College of Nanchang University , Nanchang , Jiangxi , PR China .
  • Peng W; d Experimental Class-2011 Grade .
  • Tu YM; g Department of Endocrinology , The Fourth Affiliated Hospital of Nanchang University , Nanchang , Jiangxi , PR China , and.
  • Yang YP; g Department of Endocrinology , The Fourth Affiliated Hospital of Nanchang University , Nanchang , Jiangxi , PR China , and.
  • Luo D; a Department of Physiology , Jiangxi Medical College of Nanchang University , Nanchang , Jiangxi , PR China .
  • Zou L; h Department of Radioimmunology , People's Hospital of Jiangxi Province , Nanchang , Jiangxi , PR China.
  • Liang SD; a Department of Physiology , Jiangxi Medical College of Nanchang University , Nanchang , Jiangxi , PR China .
Ann Hum Biol ; 42(5): 455-60, 2015.
Article en En | MEDLINE | ID: mdl-25353278
BACKGROUND: Fasting plasma glucose (FPG) levels are usually tightly regulated within a narrow physiologic range. Variation of FPG levels is clinically important and is strongly heritable. Several lines of evidence suggest the importance of the oestrogen receptor α (ER-α) and osteocalcin (also known as BGP, for bone Gla protein) in determining FPG; however, whether their polymorphisms are associated with FPG variation is not well understood. AIM: To investigate whether ER-a PvuII and BGP HindIII genetic polymorphisms and their potential interaction are associated with FPG variation. SUBJECTS AND METHODS: The study subjects were 328 unrelated pre-menopausal Chinese women aged 21 years and over (mean age ± SD, 33.2 ± 5.9 years), with an average FPG of 4.92 (SD = 0.81). All subjects were genotyped at the ER-α PvuII and BGP HindIII loci using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). RESULTS: The ER-α PvuII genotypes were significantly associated with FPG (p = 0.007). In addition, a significant interaction was observed of the ER-α PvuII polymorphism with BGP HindIII polymorphism on FPG variation (p = 0.013), although the BGP HindIII polymorphism was not shown to be individually associated with FPG. CONCLUSION: The PvuII polymorphism of the ER-α gene and its potential interaction with the HindIII polymorphism of the BGP gene were associated with FPG in pre-menopausal Chinese women.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Osteocalcina / Premenopausia / Receptor alfa de Estrógeno Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans País/Región como asunto: Asia Idioma: En Revista: Ann Hum Biol Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Osteocalcina / Premenopausia / Receptor alfa de Estrógeno Tipo de estudio: Risk_factors_studies Límite: Adult / Female / Humans País/Región como asunto: Asia Idioma: En Revista: Ann Hum Biol Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido