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Increased stomach cancer risk following radiotherapy for testicular cancer.
Hauptmann, M; Fossa, S D; Stovall, M; van Leeuwen, F E; Johannesen, T B; Rajaraman, P; Gilbert, E S; Smith, S A; Weathers, R E; Aleman, B M P; Andersson, M; Curtis, R E; Dores, G M; Fraumeni, J F; Hall, P; Holowaty, E J; Joensuu, H; Kaijser, M; Kleinerman, R A; Langmark, F; Lynch, C F; Pukkala, E; Storm, H H; Vaalavirta, L; van den Belt-Dusebout, A W; Travis, L B; Morton, L M.
Afiliación
  • Hauptmann M; Department of Epidemiology and Biostatistics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
  • Fossa SD; Department of Oncology, Oslo University Hospital and University of Oslo, Oslo, Norway.
  • Stovall M; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • van Leeuwen FE; Department of Epidemiology and Biostatistics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
  • Johannesen TB; Cancer Registry of Norway, Oslo, Norway.
  • Rajaraman P; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
  • Gilbert ES; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
  • Smith SA; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Weathers RE; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Aleman BM; 1] Department of Epidemiology and Biostatistics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands [2] Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Andersson M; Department of Oncology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Curtis RE; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
  • Dores GM; 1] Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA [2] Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA.
  • Fraumeni JF; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
  • Hall P; 1] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden [2] Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Holowaty EJ; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
  • Joensuu H; Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.
  • Kaijser M; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Kleinerman RA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
  • Langmark F; Cancer Registry of Norway, Oslo, Norway.
  • Lynch CF; Department of Epidemiology, University of Iowa, Iowa City, IA, USA.
  • Pukkala E; 1] Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland [2] School of Health Sciences, University of Tampere, Tampere, Finland.
  • Storm HH; Cancer Prevention and Documentation, Danish Cancer Society, Copenhagen, Denmark.
  • Vaalavirta L; Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland.
  • van den Belt-Dusebout AW; Department of Epidemiology and Biostatistics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
  • Travis LB; Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA.
  • Morton LM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
Br J Cancer ; 112(1): 44-51, 2015 Jan 06.
Article en En | MEDLINE | ID: mdl-25349972
BACKGROUND: Abdominal radiotherapy for testicular cancer (TC) increases risk for second stomach cancer, although data on the radiation dose-response relationship are sparse. METHODS: In a cohort of 22,269 5-year TC survivors diagnosed during 1959-1987, doses to stomach subsites were estimated for 92 patients who developed stomach cancer and 180 matched controls. Chemotherapy details were recorded. Odds ratios (ORs) were estimated using logistic regression. RESULTS: Cumulative incidence of second primary stomach cancer was 1.45% at 30 years after TC diagnosis. The TC survivors who received radiotherapy (87 (95%) cases, 151 (84%) controls) had a 5.9-fold (95% confidence interval (CI) 1.7-20.7) increased risk of stomach cancer. Risk increased with increasing stomach dose (P-trend<0.001), with an OR of 20.5 (3.7-114.3) for ⩾50.0 Gy compared with <10 Gy. Radiation-related risks remained elevated ⩾20 years after exposure (P<0.001). Risk after any chemotherapy was not elevated (OR=1.1; 95% CI 0.5-2.5; 14 cases and 23 controls). CONCLUSIONS: Radiotherapy for TC involving parts of the stomach increased gastric cancer risk for several decades, with the highest risks after stomach doses of ⩾30 Gy. Clinicians should be aware of these excesses when previously irradiated TC survivors present with gastrointestinal symptoms and when any radiotherapy is considered in newly diagnosed TC patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Neoplasias Testiculares / Neoplasias Inducidas por Radiación Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Neoplasias Testiculares / Neoplasias Inducidas por Radiación Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido