Polymorphisms of TERT and CLPTM1L and the risk of hepatocellular carcinoma in Chinese males.

Su, Ling-Yan; Li, Xue-Lian; Shen, Li; Zhang, Yue; Zhao, Meng-Meng; Yin, Zhi-Hua; Su, Hong-Ying; Zhou, Bao-Sen

Su, Ling-Yan; Li, Xue-Lian; Shen, Li; Zhang, Yue; Zhao, Meng-Meng; Yin, Zhi-Hua; Su, Hong-Ying; Zhou, Bao-Sen.

Afiliación

Su LY; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China E-mail : bszhou@mail.cmu.edu.cn.

Asian Pac J Cancer Prev ; 15(19): 8197-201, 2014.

Article en En | MEDLINE | ID: mdl-25339005

RESUMEN

BACKGROUND: Telomerase reverse transcriptase (TERT) and cleft lip and palate trans-membrane 1 like (CLPTM1L) genes located on chromosome 5p15.33 are known to influence the susceptibility to various cancers. Here, we examined the association of TERT and CLPTM1L single nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Genotyping of TERT SNP rs2736098 and CLPTM1L SNP rs401681 was performed using TaqMan allelic discrimination assays in a case-control study of 201 HCC cases and 210 controls in a Chinese male population. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression analyses. RESULTS: Both the rs2736098 T allele of TERT and the rs401681 T allele of CLPTM1L were associated with a significantly increased risk of HCC (adjusted odds ratio [OR]=1.605, 95% confidence interval [CI]=1.164-2.213; adjusted OR=1.399, 95%CI=1.002-1.955, respectively). Individuals carrying both TERT and CLPTM1L risk genotypes had an even higher risk of HCC (adjusted OR=4.420, 95%CI= 2.319-8.425). The TERT rs2736098 T allele was also significantly associated with the level of the HCC clinical indicator alpha-fetoprotein (P=0.026). CONCLUSIONS: Our results show that genetic variants of TERT and CLPTM1L may contribute to HCC susceptibility in Chinese males.

Asunto(s)

Pueblo Asiatico/genética; Carcinoma Hepatocelular/genética; Neoplasias Hepáticas/genética; Proteínas de la Membrana/genética; Proteínas de Neoplasias/genética; Polimorfismo Genético/genética; Telomerasa/genética; Adulto; Anciano; Anciano de 80 o más Años; Carcinoma Hepatocelular/patología; Estudios de Casos y Controles; Estudios de Seguimiento; Predisposición Genética a la Enfermedad; Genotipo; Humanos; Neoplasias Hepáticas/patología; Masculino; Persona de Mediana Edad; Estadificación de Neoplasias; Oportunidad Relativa; Reacción en Cadena de la Polimerasa; Pronóstico

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Carcinoma Hepatocelular / Telomerasa / Pueblo Asiatico / Neoplasias Hepáticas / Proteínas de la Membrana / Proteínas de Neoplasias Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Asian Pac J Cancer Prev Asunto de la revista: NEOPLASIAS Año: 2014 Tipo del documento: Article Pais de publicación: Tailandia

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links