Prevalence and determinants of fatty liver in normal-weight and overweight young adults. The Cardiovascular Risk in Young Finns Study.

Suomela, Emmi; Oikonen, Mervi; Virtanen, Johanna; Parkkola, Riitta; Jokinen, Eero; Laitinen, Tomi; Hutri-Kähönen, Nina; Kähönen, Mika; Lehtimäki, Terho; Taittonen, Leena; Tossavainen, Päivi; Jula, Antti; Loo, Britt-Marie; Mikkilä, Vera; Younossi, Zobair; Viikari, Jorma S A; Juonala, Markus; Raitakari, Olli T

Suomela, Emmi; Oikonen, Mervi; Virtanen, Johanna; Parkkola, Riitta; Jokinen, Eero; Laitinen, Tomi; Hutri-Kähönen, Nina; Kähönen, Mika; Lehtimäki, Terho; Taittonen, Leena; Tossavainen, Päivi; Jula, Antti; Loo, Britt-Marie; Mikkilä, Vera; Younossi, Zobair; Viikari, Jorma S A; Juonala, Markus; Raitakari, Olli T.

Afiliación

Suomela E; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku , Turku , Finland.

Ann Med ; 47(1): 40-6, 2015 Feb.

Article en En | MEDLINE | ID: mdl-25333756

RESUMEN

BACKGROUND AND AIMS: Fatty liver may have different determinants in normal-weight and in obese individuals. We measured factors associated with fatty liver in 863 normal-weight (BMI < 25) and 1135 overweight/obese (BMI ≥ 25) young and middle-aged adults (45% male, age 34-49 years) in the population-based Cardiovascular Risk in Young Finns Study. METHODS AND RESULTS: The prevalence of fatty liver detected with ultrasound was 29% in overweight/obese and 5% in normal-weight participants. In overweight/obese, the independent correlates were waist circumference (odds ratio for 1 standard deviation increase = 3.78), alanine transaminase (2.11), BMI (2.00), male sex (1.74), triglycerides (1.44), systolic blood pressure (1.31), fasting insulin (1.23), and physical activity (0.76). In normal weight, the independent correlates included alanine transaminase (3.05), smoking (2.56), systolic blood pressure (1.54), and alcohol intake (1.41). In normal-weight participants, the associations with fatty liver were stronger for alcohol intake and smoking, and weaker for triglycerides, than in overweight/obese participants (P for interaction < 0.05). CONCLUSION: Prevalence of fatty liver was 29% in overweight/obese and 5% in normal-weight adults. Differences in factors associated with fatty liver were seen between these two groups: alcohol intake and smoking were more strongly and triglycerides more weakly associated in normal-weight than in overweight/obese participants.

Asunto(s)

Peso Corporal; Hígado Graso/epidemiología; Hígado Graso/etiología; Sobrepeso/complicaciones; Adulto; Alanina Transaminasa/sangre; Consumo de Bebidas Alcohólicas/sangre; Presión Sanguínea; Índice de Masa Corporal; Estudios de Cohortes; Ayuno/sangre; Hígado Graso/sangre; Femenino; Finlandia/epidemiología; Humanos; Insulina/sangre; Masculino; Persona de Mediana Edad; Actividad Motora; Sobrepeso/sangre; Prevalencia; Factores de Riesgo; Factores Sexuales; Fumar/sangre; Triglicéridos/sangre; Circunferencia de la Cintura

Palabras clave

Cohort studies; epidemiologic factors; fatty liver; normal body weight; overweight; prevalence

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peso Corporal / Sobrepeso / Hígado Graso Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Ann Med Asunto de la revista: MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido

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