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Cytopenia and Bone Marrow Dysplasia in a Case of Wilson's Disease.
Rau, Aarathi R; Usha, M; Mallya, Pooja; Rau, A T K.
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  • Rau AR; Department of Pathology, MS Ramaiah Medical College, Bangalore, 560054 India.
  • Usha M; Department of Pathology, MS Ramaiah Medical College, Bangalore, 560054 India.
  • Mallya P; Department of Paediatrics, MS Ramaiah Medical College, Bangalore, 560054 India.
  • Rau AT; Department of Paediatrics, MS Ramaiah Medical College, Bangalore, 560054 India.
Indian J Hematol Blood Transfus ; 30(Suppl 1): 433-6, 2014 Sep.
Article en En | MEDLINE | ID: mdl-25332639
We describe a sixteen year old with Wilson's disease on copper chelation and subsequent high dose oral zinc who developed severe anemia and neutropenia. Bone marrow aspirate done to evaluate the cause of bicytopenia revealed trilineage dysplasia. Correlating the clinical context with bone marrow and biochemical parameters, copper deficiency was suspected and he was given a trial of therapy, following which the hematological parameters improved. This case highlights hypocupremia as a reversible cause of bone marrow dysplasia in patients with Wilson's disease on chelation, where serum copper levels are not useful in the diagnosis. We also believe that monitoring of the blood counts in patients on copper chelation may provide a clue to impending copper deficiency.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Indian J Hematol Blood Transfus Año: 2014 Tipo del documento: Article Pais de publicación: India
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Indian J Hematol Blood Transfus Año: 2014 Tipo del documento: Article Pais de publicación: India