Aza-Michael reaction of 12-N-carboxamide of (-)-cytisine under high pressure conditions.

Tsypysheva, Inna P; Lobov, Alexander N; Kovalskaya, Alena V; Petrova, Polina R; Ivanov, Sergey P; Rameev, Shamil A; Borisevich, Sophia S; Safiullin, Rustam L; Yunusov, Marat S

Tsypysheva, Inna P; Lobov, Alexander N; Kovalskaya, Alena V; Petrova, Polina R; Ivanov, Sergey P; Rameev, Shamil A; Borisevich, Sophia S; Safiullin, Rustam L; Yunusov, Marat S.

Afiliación

Tsypysheva IP; a Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences , 71, pr. Oktyabrya, 450054 Ufa , Russian Federation.

Nat Prod Res ; 29(2): 141-8, 2015.

Article en En | MEDLINE | ID: mdl-25330752

RESUMEN

The first example of aza-Michael reaction of 12-N-carboxamide of quinolizidine alkaloid (-)-cytisine with α,ß-unsaturated ketones, dimethyl acetylenedicarboxylate and ß-nitrostyrene under high pressure condition has been described. It has been shown that the [4+2]-cycloaddition takes place in the case with N-phenylmaleimide.

Asunto(s)

Alcaloides/química; Quinolizidinas/química; Alcaloides/síntesis química; Alquinos/química; Azocinas/síntesis química; Azocinas/química; Cetonas/química; Maleimidas/química; Estructura Molecular; Quinolizidinas/síntesis química; Quinolizinas/síntesis química; Quinolizinas/química; Estereoisomerismo; Estirenos/química

Palabras clave

()-cytisine; aza-Michael reaction; high pressure

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alcaloides / Quinolizidinas Idioma: En Revista: Nat Prod Res Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido

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