[A case of an elderly diabetic patient with dementia effectively treated with weekly exenatide].
Nihon Ronen Igakkai Zasshi
; 51(4): 375-80, 2014.
Article
en Ja
| MEDLINE
| ID: mdl-25327373
A 74-year-old man with diabetes mellitus since 64 years of age had been treated with glimepiride, metformin and alogliptin; however, his glycemic control remained poor, i.e., a casual blood glucose level of 318 mg/dl, HbA1c level of 10.6% and glycated albumin level of 24.9%. Although his blood glucose level improved with intensive insulin therapy, he exhibited dementia with an MMSE score of 9/30 and was unable to continue insulin injections by himself, thus rejecting his family's help. The extended-release form of the GLP-1 agonist exenatide (Bydureon(®)) was recently introduced in Japan. This new anti-diabetic agent enables the administration of once-weekly type 2 diabetes treatment that delivers a continuous dose of exenatide in a single weekly injection. We employed weekly exenatide therapy in combination with oral hypoglycemic agents in this case. The patient visited our outpatient clinic for injections every week, showing a remarkable improvement in his HbA1c level, from 10.7% to 7.1% in five months. Subcutaneous induration was the only side effect of weekly exenatide injection. Weekly exenatide therapy can be easily managed by other caregivers and is expected to be a useful treatment approach in elderly diabetic patients with dementia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Ponzoñas
/
Demencia
/
Complicaciones de la Diabetes
/
Diabetes Mellitus
/
Hipoglucemiantes
Límite:
Aged
/
Humans
/
Male
Idioma:
Ja
Revista:
Nihon Ronen Igakkai Zasshi
Año:
2014
Tipo del documento:
Article
Pais de publicación:
Japón