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Current status of antisense RNA-mediated gene regulation in Listeria monocytogenes.
Schultze, Tilman; Izar, Benjamin; Qing, Xiaoxing; Mannala, Gopala K; Hain, Torsten.
Afiliación
  • Schultze T; Department of Medicine, Institute of Medical Microbiology, Justus-Liebig University Giessen Giessen, Germany.
  • Izar B; Department of Medicine, Massachusetts General Hospital and Harvard Medical School Boston, MA, USA.
  • Qing X; Department of Medicine, Institute of Medical Microbiology, Justus-Liebig University Giessen Giessen, Germany.
  • Mannala GK; Department of Medicine, Institute of Medical Microbiology, Justus-Liebig University Giessen Giessen, Germany.
  • Hain T; Department of Medicine, Institute of Medical Microbiology, Justus-Liebig University Giessen Giessen, Germany.
Front Cell Infect Microbiol ; 4: 135, 2014.
Article en En | MEDLINE | ID: mdl-25325017
Listeria monocytogenes is a Gram-positive human-pathogen bacterium that served as an experimental model for investigating fundamental processes of adaptive immunity and virulence. Recent novel technologies allowed the identification of several hundred non-coding RNAs (ncRNAs) in the Listeria genome and provided insight into an unexpected complex transcriptional machinery. In this review, we discuss ncRNAs that are encoded on the opposite strand of the target gene and are therefore termed antisense RNAs (asRNAs). We highlight mechanistic and functional concepts of asRNAs in L. monocytogenes and put these in context of asRNAs in other bacteria. Understanding asRNAs will further broaden our knowledge of RNA-mediated gene regulation and may provide targets for diagnostic and antimicrobial development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Bacteriano / Regulación Bacteriana de la Expresión Génica / ARN sin Sentido / Listeria monocytogenes Idioma: En Revista: Front Cell Infect Microbiol Año: 2014 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Bacteriano / Regulación Bacteriana de la Expresión Génica / ARN sin Sentido / Listeria monocytogenes Idioma: En Revista: Front Cell Infect Microbiol Año: 2014 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza