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A Rheological Study of Biodegradable Injectable PEGMC/HA Composite Scaffolds.
Jiao, Yang; Gyawali, Dipendra; Stark, Joseph M; Akcora, Pinar; Nair, Parvathi; Tran, Richard T; Yang, Jian.
Afiliación
  • Jiao Y; Department of Chemical Engineering & Materials Science, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
  • Gyawali D; Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76010, USA ; Joint Biomedical Engineering Program, The University of Texas Southwestern Medical Center and The University of Texas at Arlington, Dallas, TX 75390, USA.
  • Stark JM; Department of Chemical Engineering, University of Missouri, Columbia, MO 65211, USA.
  • Akcora P; Department of Chemical Engineering & Materials Science, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
  • Nair P; Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76010, USA ; Joint Biomedical Engineering Program, The University of Texas Southwestern Medical Center and The University of Texas at Arlington, Dallas, TX 75390, USA.
  • Tran RT; Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76010, USA ; Joint Biomedical Engineering Program, The University of Texas Southwestern Medical Center and The University of Texas at Arlington, Dallas, TX 75390, USA.
  • Yang J; Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76010, USA ; Joint Biomedical Engineering Program, The University of Texas Southwestern Medical Center and The University of Texas at Arlington, Dallas, TX 75390, USA.
Soft Matter ; 8(5): 1499-1507, 2012.
Article en En | MEDLINE | ID: mdl-25309615
Injectable biodegradable hydrogels, which can be delivered in a minimally invasive manner and formed in situ, have found a number of applications in pharmaceutical and biomedical applications, such as drug delivery and tissue engineering. We have recently developed an in situ crosslinkable citric acid-based biodegradable poly (ethylene glycol) maleate citrate (PEGMC)/hydroxyapatite (HA) composite, which shows promise for use in bone tissue engineering. In this study, the mechanical properties of the PEGMC/HA composites were studied in dynamic linear rheology experiments. Critical parameters such as monomer ratio, crosslinker, initiator, and HA concentrations were varied to reveal their effect on the extent of crosslinking as they control the mechanical properties of the resultant gels. The rheological studies, for the first time, allowed us investigating the physical interactions between HA and citric acid-based PEGMC. Understanding the viscoelastic properties of the injectable gel composites is crucial in formulating suitable injectable PEGMC/HA scaffolds for bone tissue engineering, and should also promote the other biomedical applications based on citric acid-based biodegradable polymers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Soft Matter Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Soft Matter Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido