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Quantification of myocardial blood flow in absolute terms using (82)Rb PET imaging: the RUBY-10 Study.
Nesterov, Sergey V; Deshayes, Emmanuel; Sciagrà, Roberto; Settimo, Leonardo; Declerck, Jerome M; Pan, Xiao-Bo; Yoshinaga, Keiichiro; Katoh, Chietsugu; Slomka, Piotr J; Germano, Guido; Han, Chunlei; Aalto, Ville; Alessio, Adam M; Ficaro, Edward P; Lee, Benjamin C; Nekolla, Stephan G; Gwet, Kilem L; deKemp, Robert A; Klein, Ran; Dickson, John; Case, James A; Bateman, Timothy; Prior, John O; Knuuti, Juhani M.
Afiliación
  • Nesterov SV; Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
  • Deshayes E; IM Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg, Russia.
  • Sciagrà R; Lausanne University Hospital, Lausanne, Switzerland.
  • Settimo L; Regional Cancer Institute of Montpellier (ICM) - Val d'Aurelle, Montpellier, France.
  • Declerck JM; University of Florence, Florence, Italy.
  • Pan XB; University of Florence, Florence, Italy.
  • Yoshinaga K; Siemens Molecular Imaging, Oxford, United Kingdom.
  • Katoh C; Siemens Molecular Imaging, Oxford, United Kingdom.
  • Slomka PJ; Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Germano G; Hokkaido University Graduate School of Medicine, Sapporo, Japan.
  • Han C; Cedars-Sinai Medical Center, Los Angeles, California, United States.
  • Aalto V; Cedars-Sinai Medical Center, Los Angeles, California, United States.
  • Alessio AM; Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
  • Ficaro EP; Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
  • Lee BC; University of Washington, Seattle, Washington, United States.
  • Nekolla SG; University of Michigan Health Systems, Ann Arbor, Michigan, United States.
  • Gwet KL; INVIA Medical Imaging Solutions, Ann Arbor, Michigan, United States.
  • deKemp RA; Department of Nuclear Medicine, Technical University, Munich, Germany.
  • Klein R; Advanced Analytics LLC, Gaithersburg, Maryland, United States.
  • Dickson J; National Cardiac PET Center, University of Ottawa Heart Institute, Ottawa, Canada.
  • Case JA; National Cardiac PET Center, University of Ottawa Heart Institute, Ottawa, Canada.
  • Bateman T; University College London, London, United Kingdom.
  • Prior JO; Cardiovascular Imaging Technologies, Kansas City, Missouri, United States.
  • Knuuti JM; Cardiovascular Imaging Technologies, Kansas City, Missouri, United States.
JACC Cardiovasc Imaging ; 7(11): 1119-1127, 2014 Nov.
Article en En | MEDLINE | ID: mdl-25306543
OBJECTIVES: The purpose of this study was to compare myocardial blood flow (MBF) and myocardial flow reserve (MFR) estimates from rubidium-82 positron emission tomography ((82)Rb PET) data using 10 software packages (SPs) based on 8 tracer kinetic models. BACKGROUND: It is unknown how MBF and MFR values from existing SPs agree for (82)Rb PET. METHODS: Rest and stress (82)Rb PET scans of 48 patients with suspected or known coronary artery disease were analyzed in 10 centers. Each center used 1 of 10 SPs to analyze global and regional MBF using the different kinetic models implemented. Values were considered to agree if they simultaneously had an intraclass correlation coefficient >0.75 and a difference <20% of the median across all programs. RESULTS: The most common model evaluated was the Ottawa Heart Institute 1-tissue compartment model (OHI-1-TCM). MBF values from 7 of 8 SPs implementing this model agreed best. Values from 2 other models (alternative 1-TCM and Axially distributed) also agreed well, with occasional differences. The MBF results from other models (e.g., 2-TCM and retention) were less in agreement with values from OHI-1-TCM. CONCLUSIONS: SPs using the most common kinetic model-OHI-1-TCM-provided consistent results in measuring global and regional MBF values, suggesting that they may be used interchangeably to process data acquired with a common imaging protocol.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Radioisótopos de Rubidio / Radiofármacos / Imagen de Perfusión Miocárdica Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte / Asia / Europa Idioma: En Revista: JACC Cardiovasc Imaging Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / DIAGNOSTICO POR IMAGEM Año: 2014 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Radioisótopos de Rubidio / Radiofármacos / Imagen de Perfusión Miocárdica Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte / Asia / Europa Idioma: En Revista: JACC Cardiovasc Imaging Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / DIAGNOSTICO POR IMAGEM Año: 2014 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos