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A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation.
Lee, Sanghee; Nam, Youngpyo; Koo, Ja Young; Lim, Donghyun; Park, Jongmin; Ock, Jiyeon; Kim, Jaehong; Suk, Kyoungho; Park, Seung Bum.
Afiliación
  • Lee S; Department of Chemistry, Seoul National University, Seoul, Korea.
  • Nam Y; Department of Pharmacology, Brain Science and Engineering Institute, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine, Daegu, Korea.
  • Koo JY; Department of Chemistry, Seoul National University, Seoul, Korea.
  • Lim D; Department of Biophysics and Chemical Biology/N-Bio Institute, Seoul National University, Seoul, Korea.
  • Park J; Department of Chemistry, Seoul National University, Seoul, Korea.
  • Ock J; Department of Pharmacology, Brain Science and Engineering Institute, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine, Daegu, Korea.
  • Kim J; Department of Pharmacology, Brain Science and Engineering Institute, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine, Daegu, Korea.
  • Suk K; Department of Pharmacology, Brain Science and Engineering Institute, BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University School of Medicine, Daegu, Korea.
  • Park SB; 1] Department of Chemistry, Seoul National University, Seoul, Korea. [2] Department of Biophysics and Chemical Biology/N-Bio Institute, Seoul National University, Seoul, Korea.
Nat Chem Biol ; 10(12): 1055-60, 2014 Dec.
Article en En | MEDLINE | ID: mdl-25306442
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Procesamiento Proteico-Postraduccional / Microglía / Fármacos Neuroprotectores / Proteína HMGB1 / Proteína HMGB2 / Compuestos Heterocíclicos de 4 o más Anillos / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Chem Biol Asunto de la revista: BIOLOGIA / QUIMICA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Procesamiento Proteico-Postraduccional / Microglía / Fármacos Neuroprotectores / Proteína HMGB1 / Proteína HMGB2 / Compuestos Heterocíclicos de 4 o más Anillos / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Chem Biol Asunto de la revista: BIOLOGIA / QUIMICA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos