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Long-term effects of Roux-en-Y gastric bypass on postprandial plasma lipid and bile acids kinetics in female non diabetic subjects: A cross-sectional pilot study.
De Giorgi, Sara; Campos, Vanessa; Egli, Leonie; Toepel, Ulrike; Carrel, Guillaume; Cariou, Bertrand; Rainteau, Dominique; Schneiter, Philippe; Tappy, Luc; Giusti, Vittorio.
Afiliación
  • De Giorgi S; Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland.
  • Campos V; Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland.
  • Egli L; Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland.
  • Toepel U; Departments of Radiology and Clinical Neurosciences, University Hospital and University of Lausanne, Switzerland.
  • Carrel G; Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland.
  • Cariou B; INSERM, UMR1087-CNRS UMR6291, l'Institut du Thorax, Faculté de Médecine, Université de Nantes, F-44000 Nantes, France.
  • Rainteau D; Sorbonne Universités - UPMC Univ Paris 06, INSERM ERL 1157, CNRS UMR 7203 LBM, CHU Saint-Antoine, Paris, France.
  • Schneiter P; Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland.
  • Tappy L; Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland. Electronic address: luc.tappy@unil.ch.
  • Giusti V; Center for Metabolic Diseases, Department of Internal Medicine, Broye Intercantonal Hospital, Estavayer-le-lac, Switzerland.
Clin Nutr ; 34(5): 911-7, 2015 Oct.
Article en En | MEDLINE | ID: mdl-25306425
BACKGROUND AND AIMS: Formerly obese patients having undergone Roux-en-Y gastric bypass (RYGB) display both an accelerated digestion and absorption of carbohydrate and an increased plasma glucose clearance rate after meal ingestion. How RYGB effects postprandial kinetics of dietary lipids has yet not been investigated. METHODS: Plasma triglyceride (TG), apoB48, total apoB, bile acids (BA), fibroblast growth factor 19 (FGF19), and cholecystokinin (CCK) were measured in post-absorptive conditions and over 4-h following the ingestion of a mixed test meal in a cross-sectional, pilot study involving 11 formerly obese female patients 33.8 ± 16.4 months after RYGB surgery and in 11 weight- and age-matched female control participants. RESULTS: Compared to controls, RYGB patients had faster (254 ± 14 vs. 327 ± 7 min, p < 0.05) and lower (0.14 ± 0.04 vs. 0.35 ± 0.07 mM, p < 0.05) peak TG responses, but their peak apoB48 responses tended to be higher (2692 ± 336 vs. 1841 ± 228 ng/ml, p = 0.09). Their postprandial total BA concentrations were significantly increased and peaked earlier after meal ingestion than in controls. Their FGF19 and CCK concentrations also peaked earlier and to a higher value. CONCLUSIONS: The early postprandial apoB48 and BA responses indicate that RYGB accelerated the rate of dietary lipid absorption. The lower postprandial peak TG strongly suggests that the RYGB simultaneously increased the clearance of TG-rich lipoproteins. CLINICAL TRIAL REGISTRATION: NCT01891591.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apolipoproteínas B / Triglicéridos / Ácidos y Sales Biliares / Derivación Gástrica / Periodo Posprandial / Apolipoproteína B-48 Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans Idioma: En Revista: Clin Nutr Año: 2015 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apolipoproteínas B / Triglicéridos / Ácidos y Sales Biliares / Derivación Gástrica / Periodo Posprandial / Apolipoproteína B-48 Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans Idioma: En Revista: Clin Nutr Año: 2015 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido