Neuromodulatory role of serotonin in the anticonvulsant activity of 2-phenylbenzoate of 3-diethylamino-1-propanol.HCl (JAW-669).
Physiol Behav
; 46(1): 35-7, 1989 Jul.
Article
en En
| MEDLINE
| ID: mdl-2530601
The role of serotonin in the mediation of the anticonvulsant activity of JAW-669 was investigated against maximal electric shock (MES)-induced seizures in mice. A dose-dependent protection against seizures was provided by JAW-669 (4, 6 and 8 mg/kg, IP) and the calculated ED50 value was 6.01 mg/kg, IP. Pretreatment of mice with 5-hydroxytryptophan (50 mg/kg, IP) 2 hr before the administration of JAW-669 (6.01 mg/kg, IP) was found to cause a 40% increase in the ability of JAW-669 to provide protection against MES-induced seizures. Similar pretreatment with tryptophan (100 mg/kg, IP, 1 hr) caused a 30% decrease in the anticonvulsant activity of JAW-669. Prior administration of p-chlorophenylalanine (300 mg/kg, IP, 48 hr) and methysergide (10 mg/kg, IP; 0.5 hr) before administration of JAW-699 caused a 66% and 74% decrease, respectively, in the ability of JAW-669 to provide protection against MES-induced seizures. These results suggest a facilitatory role of serotonin in the anticonvulsant activity of JAW-669.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Propanolaminas
/
Compuestos de Bifenilo
/
Encéfalo
/
Serotonina
/
Receptores de Serotonina
/
Excitación Neurológica
/
Anticonvulsivantes
Límite:
Animals
Idioma:
En
Revista:
Physiol Behav
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Estados Unidos