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Retinal vascular fractals and cognitive impairment.
Ong, Yi-Ting; Hilal, Saima; Cheung, Carol Yim-Lui; Xu, Xin; Chen, Christopher; Venketasubramanian, Narayanaswamy; Wong, Tien Yin; Ikram, Mohammad Kamran.
Afiliación
  • Ong YT; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore ; Department of NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore ; Department of Singapore Eye Research Institute, Singapore National Eye Center, Singapore.
  • Hilal S; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore ; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore ; Department of Memory, Aging and Cognition Center, National University Health System, Singapore.
  • Cheung CY; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore ; Department of Singapore Eye Research Institute, Singapore National Eye Center, Singapore ; Department of Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore.
  • Xu X; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore ; Department of Memory, Aging and Cognition Center, National University Health System, Singapore.
  • Chen C; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore ; Department of Memory, Aging and Cognition Center, National University Health System, Singapore.
  • Venketasubramanian N; Department of Neuroscience Clinic, Raffles Hospital, Singapore.
  • Wong TY; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore ; Department of Singapore Eye Research Institute, Singapore National Eye Center, Singapore ; Department of Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore.
  • Ikram MK; Department of Singapore Eye Research Institute, Singapore National Eye Center, Singapore ; Department of Memory, Aging and Cognition Center, National University Health System, Singapore ; Department of Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore.
Dement Geriatr Cogn Dis Extra ; 4(2): 305-13, 2014 May.
Article en En | MEDLINE | ID: mdl-25298774
BACKGROUND: Retinal microvascular network changes have been found in patients with age-related brain diseases such as stroke and dementia including Alzheimer's disease. We examine whether retinal microvascular network changes are also present in preclinical stages of dementia. METHODS: This is a cross-sectional study of 300 Chinese participants (age: ≥60 years) from the ongoing Epidemiology of Dementia in Singapore study who underwent detailed clinical examinations including retinal photography, brain imaging and neuropsychological testing. Retinal vascular parameters were assessed from optic disc-centered photographs using a semiautomated program. A comprehensive neuropsychological battery was administered, and cognitive function was summarized as composite and domain-specific Z-scores. Cognitive impairment no dementia (CIND) and dementia were diagnosed according to standard diagnostic criteria. RESULTS: Among 268 eligible nondemented participants, 78 subjects were categorized as CIND-mild and 69 as CIND-moderate. In multivariable adjusted models, reduced retinal arteriolar and venular fractal dimensions were associated with an increased risk of CIND-mild and CIND-moderate. Reduced fractal dimensions were associated with poorer cognitive performance globally and in the specific domains of verbal memory, visuoconstruction and visuomotor speed. CONCLUSION: A sparser retinal microvascular network, represented by reduced arteriolar and venular fractal dimensions, was associated with cognitive impairment, suggesting that early microvascular damage may be present in preclinical stages of dementia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Dement Geriatr Cogn Dis Extra Año: 2014 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Dement Geriatr Cogn Dis Extra Año: 2014 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Suiza