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Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1α and oxidative phosphorylation in melanoma.
Gopal, Y N Vashisht; Rizos, Helen; Chen, Guo; Deng, Wanleng; Frederick, Dennie T; Cooper, Zachary A; Scolyer, Richard A; Pupo, Gulietta; Komurov, Kakajan; Sehgal, Vasudha; Zhang, Jiexin; Patel, Lalit; Pereira, Cristiano G; Broom, Bradley M; Mills, Gordon B; Ram, Prahlad; Smith, Paul D; Wargo, Jennifer A; Long, Georgina V; Davies, Michael A.
Afiliación
  • Gopal YN; Departments of Melanoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas. vynanda@mdanderson.org.
  • Rizos H; Melanoma Institute of Australia and Westmead Hospital, Sydney, Australia.
  • Chen G; Departments of Melanoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
  • Deng W; Departments of Melanoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
  • Frederick DT; Massachusetts General Hospital, Boston, Massachusetts.
  • Cooper ZA; Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
  • Scolyer RA; Melanoma Institute of Australia and Westmead Hospital, Sydney, Australia.
  • Pupo G; Melanoma Institute of Australia and Westmead Hospital, Sydney, Australia.
  • Komurov K; Department of Pediatrics, University of Cincinnati, Cincinatti, Ohio.
  • Sehgal V; Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
  • Zhang J; Department of Bioinformatics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
  • Patel L; Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
  • Pereira CG; Departments of Melanoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
  • Broom BM; Department of Bioinformatics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
  • Mills GB; Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
  • Ram P; Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
  • Smith PD; Astra Zeneca, Macclesfield, United Kingdom.
  • Wargo JA; Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
  • Long GV; Melanoma Institute of Australia and Westmead Hospital, Sydney, Australia.
  • Davies MA; Departments of Melanoma Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas. Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
Cancer Res ; 74(23): 7037-47, 2014 Dec 01.
Article en En | MEDLINE | ID: mdl-25297634
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosforilación Oxidativa / Proteínas Quinasas Activadas por Mitógenos / Sistema de Señalización de MAP Quinasas / Complejos Multiproteicos / Inhibidores de Proteínas Quinasas / Serina-Treonina Quinasas TOR / Melanoma Límite: Humans Idioma: En Revista: Cancer Res Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosforilación Oxidativa / Proteínas Quinasas Activadas por Mitógenos / Sistema de Señalización de MAP Quinasas / Complejos Multiproteicos / Inhibidores de Proteínas Quinasas / Serina-Treonina Quinasas TOR / Melanoma Límite: Humans Idioma: En Revista: Cancer Res Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos