Raft formation in lipid bilayers coupled to curvature.

Sadeghi, Sina; Müller, Marcus; Vink, Richard L C

Sadeghi, Sina; Müller, Marcus; Vink, Richard L C.

Afiliación

Sadeghi S; Institute of Theoretical Physics, Georg-August-Universität Göttingen, Göttingen, Germany. Electronic address: sadeghi@theorie.physik.uni-goettingen.de.
Müller M; Institute of Theoretical Physics, Georg-August-Universität Göttingen, Göttingen, Germany.
Vink RL; Institute of Theoretical Physics, Georg-August-Universität Göttingen, Göttingen, Germany.

Biophys J ; 107(7): 1591-600, 2014 Oct 07.

Article en En | MEDLINE | ID: mdl-25296311

RESUMEN

We present computer simulations of a membrane in which the local composition is coupled to the local membrane curvature. At high temperatures (i.e., above the temperature of macroscopic phase separation), finite-sized transient domains are observed, reminiscent of lipid rafts. The domain size is in the range of hundred nanometers, and set by the membrane elastic properties. These findings are in line with the notion of the membrane as a curvature-induced microemulsion. At low temperature, the membrane phase separates. The transition to the phase-separated regime is continuous and belongs to the two-dimensional Ising universality class when the coupling to curvature is weak, but becomes first-order for strong curvature-composition coupling.

Asunto(s)

Membrana Dobles de Lípidos/química; Microdominios de Membrana/química; Método de Montecarlo; Modelos Moleculares; Transición de Fase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Método de Montecarlo / Microdominios de Membrana / Membrana Dobles de Lípidos Tipo de estudio: Health_economic_evaluation / Prognostic_studies Idioma: En Revista: Biophys J Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos

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