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Magnetic resonance imaging of ionic currents in solution: the effect of magnetohydrodynamic flow.
Balasubramanian, Mukund; Mulkern, Robert V; Wells, William M; Sundaram, Padmavathi; Orbach, Darren B.
Afiliación
  • Balasubramanian M; Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Mulkern RV; Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Wells WM; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Sundaram P; Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Orbach DB; Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Magn Reson Med ; 74(4): 1145-55, 2015 Oct.
Article en En | MEDLINE | ID: mdl-25273917
PURPOSE: Reliably detecting MRI signals in the brain that are more tightly coupled to neural activity than blood-oxygen-level-dependent fMRI signals could not only prove valuable for basic scientific research but could also enhance clinical applications such as epilepsy presurgical mapping. This endeavor will likely benefit from an improved understanding of the behavior of ionic currents, the mediators of neural activity, in the presence of the strong magnetic fields that are typical of modern-day MRI scanners. THEORY: Of the various mechanisms that have been proposed to explain the behavior of ionic volume currents in a magnetic field, only one-magnetohydrodynamic flow-predicts a slow evolution of signals, on the order of a minute for normal saline in a typical MRI scanner. METHODS: This prediction was tested by scanning a volume-current phantom containing normal saline with gradient-echo-planar imaging at 3 T. RESULTS: Greater signal changes were observed in the phase of the images than in the magnitude, with the changes evolving on the order of a minute. CONCLUSION: These results provide experimental support for the MHD flow hypothesis. Furthermore, MHD-driven cerebrospinal fluid flow could provide a novel fMRI contrast mechanism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Imagen por Resonancia Magnética / Campos Magnéticos Límite: Humans Idioma: En Revista: Magn Reson Med Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Imagen por Resonancia Magnética / Campos Magnéticos Límite: Humans Idioma: En Revista: Magn Reson Med Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos