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Predictive factors and outcomes of cochlear implantation in patients with connexin 26 mutation: a comparative study.
Rayess, Hani M; Weng, Catherine; Murray, Gail S; Megerian, Cliff A; Semaan, Maroun T.
Afiliación
  • Rayess HM; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Weng C; Ear, Nose, and Throat Institute, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA.
  • Murray GS; Ear, Nose, and Throat Institute, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA.
  • Megerian CA; Ear, Nose, and Throat Institute, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA.
  • Semaan MT; Ear, Nose, and Throat Institute, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA. Electronic address: maroun.semaan@uhhospitals.org.
Am J Otolaryngol ; 36(1): 7-12, 2015.
Article en En | MEDLINE | ID: mdl-25270357
PURPOSE: To compare hearing outcomes in patients with connexin 26 (Cx 26) mutations undergoing cochlear implantation to age matched controls and to examine whether age at implantation, gender and type of mutation were correlated with hearing outcome. MATERIALS AND METHODS: Retrospective chart review of 21 patients with Cx 26 mutations that underwent cochlear implantation compared to 18 age-matched controls. Patients' characteristics, type of mutation and pre- and postoperative short and long-term hearing thresholds, word and sentence scores were analyzed. RESULTS: There was no statistically significant difference between the Cx 26 and control group in the mean short term and mean long term post-operative pure tone averages (PTA), speech reception thresholds (SRT), word and sentence scores. Gender, age at implantation and type of connexin 26 mutation did not predict hearing outcomes. CONCLUSIONS: In patients with connexin 26 mutation, cochlear implantation provides an effective mean of auditory habilitation. Mutational status, age and gender do not seem to predict hearing outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conexinas / Implantación Coclear / Sordera / Mutación Tipo de estudio: Observational_studies / Prognostic_studies Límite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Am J Otolaryngol Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conexinas / Implantación Coclear / Sordera / Mutación Tipo de estudio: Observational_studies / Prognostic_studies Límite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Am J Otolaryngol Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos