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Inflammatory markers, oxidative stress, and antioxidant capacity in healthy allo-HSCT donors during hematopoietic stem cell mobilization.
Ilhan, Çigdem; Suyani, Elif; Sucak, Gülsan Türköz; Pasaoglu, Özge Tugçe; Aki, Sahika Zeynep; Pasaoglu, Hatice.
Afiliación
  • Ilhan Ç; Department of Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Suyani E; Department of Hematology, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Sucak GT; Department of Hematology, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Pasaoglu ÖT; Department of Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Aki SZ; Department of Hematology, Gazi University Faculty of Medicine, Ankara, Turkey.
  • Pasaoglu H; Department of Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey.
J Clin Apher ; 30(4): 197-203, 2015 Aug.
Article en En | MEDLINE | ID: mdl-25270291
The aim of this study is to investigate the impact of mobilization with granulocyte colony stimulating factor (G-CSF) and apheresis procedure on inflammatory and oxidative stress markers, and antioxidant capacity in healthy allo-HSCT donors. The study was conducted in the Stem Cell Transplantation Unit of Gazi University Hospital between October 2010 and March 2011, and 25 consecutive allo-HSCT donors were included. The alteration in the serum levels of iron, iron binding capacity, albumin, ferritin, IL-6, hs-CRP, TAC, MDA, and AOPP were determined at five different time points. (1) Prior to the first dose of G-CSF (T0), (2) preapheresis (on the fourth day of G-CSF before the apeheresis procedure) (T1), (3) immediately postapheresis (T2), (4) 24 h postapheresis (T3), and (5) a week after apheresis (T4). Serum ferritin levels increased steadily after administration of G-CSF and remained high up toT4. Both serum IL-6 and hs-CRP levels began to increase in the T1 sampling and reached to a maximum level at T3 and decreased even below the basal levels at T4. Serum AOPP levels decreased at preapheresis and postapheresis time points, while they increased at T3 and T4 samples. Serum MDA levels decreased at T1, T2, T3, and T4 samples. Serum TAC increased significantly and steadily at all time points post G-CSF. In conclusion; mobilization with G-CSF and apheresis caused a transient inflammatory reaction and a protein limited oxidative stress in healthy allo-HCT donors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Oxidativo / Trasplante de Células Madre Hematopoyéticas / Movilización de Célula Madre Hematopoyética / Inflamación / Antioxidantes Tipo de estudio: Observational_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Apher Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Oxidativo / Trasplante de Células Madre Hematopoyéticas / Movilización de Célula Madre Hematopoyética / Inflamación / Antioxidantes Tipo de estudio: Observational_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Apher Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos