CC chemokine receptor polymorphism CCR5Δ32 in Portuguese Behçet's disease patients.
Clin Exp Rheumatol
; 32(4 Suppl 84): S72-4, 2014.
Article
en En
| MEDLINE
| ID: mdl-25268662
OBJECTIVES: To investigate whether CCR5 deletion is associated with susceptibility to Behçet's disease (BD) in a Portuguese population. METHODS: A total of 122 BD patients and 227 ethnically-matched controls were studied. Genotyping of the CCR5Δ32 polymorphisms was performed using polymerase chain reaction product sizing. RESULTS: No significant differences were observed in the allelic frequencies of CCR532 between patients and controls (OR=0.820; p=0.512). Stratification for gender and for the presence of HLA-B*51 did not reveal any significant differences. CONCLUSIONS: These results indicate that CCR5Δ32 is unlikely to contribute to susceptibility to BD in Portuguese patients. This may be explained by the known functional redundancy of this signalling system.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Síndrome de Behçet
/
Receptores CCR5
/
Predisposición Genética a la Enfermedad
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Clin Exp Rheumatol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Portugal
Pais de publicación:
Italia