Your browser doesn't support javascript.
loading
Telomere length and cortisol reactivity in children of depressed mothers.
Gotlib, I H; LeMoult, J; Colich, N L; Foland-Ross, L C; Hallmayer, J; Joormann, J; Lin, J; Wolkowitz, O M.
Afiliación
  • Gotlib IH; Primary Work, Department of Psychology, Stanford University, Stanford, CA, USA.
  • LeMoult J; Primary Work, Department of Psychology, Stanford University, Stanford, CA, USA.
  • Colich NL; Primary Work, Department of Psychology, Stanford University, Stanford, CA, USA.
  • Foland-Ross LC; Primary Work, Department of Psychology, Stanford University, Stanford, CA, USA.
  • Hallmayer J; Primary Work, Department of Psychology, Stanford University, Stanford, CA, USA.
  • Joormann J; Northwestern University, Evanston, IL, USA.
  • Lin J; University of California, San Francisco, San Francisco, CA, USA.
  • Wolkowitz OM; University of California, San Francisco, San Francisco, CA, USA.
Mol Psychiatry ; 20(5): 615-20, 2015 May.
Article en En | MEDLINE | ID: mdl-25266121
A growing body of research demonstrates that individuals diagnosed with major depressive disorder (MDD) are characterized by shortened telomere length, which has been posited to underlie the association between depression and increased instances of medical illness. The temporal nature of the relation between MDD and shortened telomere length, however, is not clear. Importantly, both MDD and telomere length have been associated independently with high levels of stress, implicating dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and anomalous levels of cortisol secretion in this relation. Despite these associations, no study has assessed telomere length or its relation with HPA-axis activity in individuals at risk for depression, before the onset of disorder. In the present study, we assessed cortisol levels in response to a laboratory stressor and telomere length in 97 healthy young daughters of mothers either with recurrent episodes of depression (i.e., daughters at familial risk for depression) or with no history of psychopathology. We found that daughters of depressed mothers had shorter telomeres than did daughters of never-depressed mothers and, further, that shorter telomeres were associated with greater cortisol reactivity to stress. This study is the first to demonstrate that children at familial risk of developing MDD are characterized by accelerated biological aging, operationalized as shortened telomere length, before they had experienced an onset of depression; this may predispose them to develop not only MDD but also other age-related medical illnesses. It is critical, therefore, that we attempt to identify and distinguish genetic and environmental mechanisms that contribute to telomere shortening.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrocortisona / Telómero / Trastorno Depresivo Mayor / Relaciones Madre-Hijo Tipo de estudio: Prognostic_studies / Qualitative_research Límite: Adolescent / Child / Female / Humans Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrocortisona / Telómero / Trastorno Depresivo Mayor / Relaciones Madre-Hijo Tipo de estudio: Prognostic_studies / Qualitative_research Límite: Adolescent / Child / Female / Humans Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido