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Aberrant expression of caspase 14 in salivary gland carcinomas.
Lemound, Juliana; Stucki-Koch, Angelika; Stoetzer, Marcus; Kokemüller, Horst; Gellrich, Nils-Claudius; Kreipe, Hans; Hussein, Kais.
Afiliación
  • Lemound J; Department of Craniomaxillofacial Surgery, Hannover Medical School, Hannover, Germany.
  • Stucki-Koch A; Institute of Pathology, Hannover Medical School, Hannover, Germany.
  • Stoetzer M; Department of Craniomaxillofacial Surgery, Hannover Medical School, Hannover, Germany.
  • Kokemüller H; Department of Craniomaxillofacial Surgery, Hannover Medical School, Hannover, Germany.
  • Gellrich NC; Department of Craniomaxillofacial Surgery, Hannover Medical School, Hannover, Germany.
  • Kreipe H; Institute of Pathology, Hannover Medical School, Hannover, Germany.
  • Hussein K; Institute of Pathology, Hannover Medical School, Hannover, Germany.
J Oral Pathol Med ; 44(6): 444-8, 2015 Jul.
Article en En | MEDLINE | ID: mdl-25257949
OBJECTIVES: Caspase 14 is reduced in adenocarcinomas of the stomach and colon. In contrast, breast and lung adenocarcinomas frequently show an overexpression of caspase 14. Salivary gland adenocarcinomas have not been evaluated for potential aberrant caspase 14 expression. MATERIALS AND METHODS: Samples from salivary gland carcinomas (n = 43) were analysed by immunohistochemistry (caspase 14, filaggrin, GATA3 and Ki67) and fluorescence in situ hybridization. RESULTS: Caspase 14 is not expressed in normal salivary glands, while in a subfraction of carcinomas (32%) an aberrant expression was found. Filaggrin could not be detected. Caspase 14 staining was not associated with tumour dedifferentiation, GATA3 expression or amplification of gene locus 19p13. CONCLUSION: In summary, aberrant expression of caspase 14 can be found in a subfraction of salivary gland carcinomas but could not be used as a biomarker for a specific carcinoma subtype of the salivary gland.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de las Glándulas Salivales / Carcinoma de Células Escamosas / Caspasa 14 / Neoplasias de Cabeza y Cuello Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Oral Pathol Med Asunto de la revista: ODONTOLOGIA / PATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de las Glándulas Salivales / Carcinoma de Células Escamosas / Caspasa 14 / Neoplasias de Cabeza y Cuello Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Oral Pathol Med Asunto de la revista: ODONTOLOGIA / PATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Dinamarca