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Getting rhythm: how do babies do it?
Joseph, Desaline; Chong, Nelson W; Shanks, Morag E; Rosato, Ezio; Taub, Nick A; Petersen, Stewart A; Symonds, Michael E; Whitehouse, William P; Wailoo, Michael.
Afiliación
  • Joseph D; Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK.
  • Chong NW; College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK Health and Human Sciences, University of Westminster, London, UK.
  • Shanks ME; College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK Nuffield lab of Ophthalmology, University of Oxford, Oxford, UK.
  • Rosato E; College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK.
  • Taub NA; College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK.
  • Petersen SA; College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK.
  • Symonds ME; Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK.
  • Whitehouse WP; Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, Nottingham, UK.
  • Wailoo M; College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, UK.
Arch Dis Child Fetal Neonatal Ed ; 100(1): F50-4, 2015 Jan.
Article en En | MEDLINE | ID: mdl-25245173
OBJECTIVES: To investigate the emergence of biological rhythms in the first months of life in human infants, by measuring age-related changes in core body temperature during night-time sleep, hormones (cortisol and 6-sulfatoxymelatonin) and the expression of a clock-controlled gene H3f3b in oral epithelial cells. DESIGN: Observational longitudinal study. SETTING: We measured overnight core body temperature, actigraphy, day-night urinary cortisol and 6-sulfatoxymelatonin, as well as circadian gene expression, in infants at home from March 2007 to July 2008 in Leicester. PARTICIPANTS: We recruited 35 healthy Caucasian infants who were born at term. They were monitored from 6 to 18 weeks of age. RESULTS: At 8 weeks of age the day-night rhythm of cortisol secretion was the first to appear followed by 6-sulfatoxymelatonin 1 week later; at the same time that night-time sleep was established. At 10 weeks, the maximum fall in deep body temperature occurred with the onset of night-time sleep, followed at 11 weeks by the rhythmical expression of the H3f3b gene. CONCLUSIONS: In human infants, there is a clear sequential pattern for the emergence of diurnal biological rhythms between 6 and 18 weeks of postnatal age, led by the secretion of cortisol and linked with the establishment of consolidated night-time sleep. It is likely that this represents part of a maturation and adaption process as infants gain equilibrium with their external environment after birth.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Temperatura Corporal / Hidrocortisona / Ritmo Circadiano / Melatonina Tipo de estudio: Observational_studies Límite: Female / Humans / Infant / Male Idioma: En Revista: Arch Dis Child Fetal Neonatal Ed Asunto de la revista: PEDIATRIA / PERINATOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Temperatura Corporal / Hidrocortisona / Ritmo Circadiano / Melatonina Tipo de estudio: Observational_studies Límite: Female / Humans / Infant / Male Idioma: En Revista: Arch Dis Child Fetal Neonatal Ed Asunto de la revista: PEDIATRIA / PERINATOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido