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Ligature-induced peri-implantitis in mice.
Pirih, F Q; Hiyari, S; Barroso, A D V; Jorge, A C A; Perussolo, J; Atti, E; Tetradis, S; Camargo, P M.
Afiliación
  • Pirih FQ; Section of Periodontics, University of California, Los Angeles, CA, USA.
  • Hiyari S; Section of Periodontics, University of California, Los Angeles, CA, USA.
  • Barroso AD; Universidade Federal do Espirito Santo, Vitoria, Brazil.
  • Jorge AC; Universidade Estadual de Ponta Grossa, Ponta Grossa, Brazil.
  • Perussolo J; Universidade Estadual de Ponta Grossa, Ponta Grossa, Brazil.
  • Atti E; Section of Periodontics, University of California, Los Angeles, CA, USA.
  • Tetradis S; Section of Oral Radiology, University of California, Los Angeles, CA, USA.
  • Camargo PM; Section of Periodontics, University of California, Los Angeles, CA, USA.
J Periodontal Res ; 50(4): 519-24, 2015 Aug.
Article en En | MEDLINE | ID: mdl-25244403
BACKGROUND AND OBJECTIVE: Peri-implantitis has a prevalence of 11-47%, involves destruction of peri-implant bone and may lead to implant loss. A detailed understanding of the pathogenesis of peri-implantitis is lacking. The objective of this study was to develop a murine model of experimental peri-implantitis. MATERIAL AND METHODS: Machined, smooth-surface, screw-shaped titanium implants were placed in the healed alveolar bone of the left maxillary molars of C57BL/6J male mice, 8 wk after tooth extraction. Peri-implantitis was induced by securing silk ligatures around the head of the implant fixtures. Implant survival and peri-implant bone levels were analyzed by micro-computed tomography (micro-CT) scans and histology, 12 wk after ligature placement. RESULTS: Implant survival was 60% (six of 10) for implants with ligatures and 100% (eight of eight) for controls. Micro-CT revealed significantly greater bone loss around the implants that received ligatures and that survived, compared with controls. The radiographic findings were confirmed via histology and toluidine blue staining. CONCLUSION: This study describes a murine model of experimental peri-implantitis around screw-shaped titanium implants placed in the edentulous alveolar bone. This model should be a useful tool to dissect pathogenic mechanisms of peri-implantitis and evaluate potential treatment interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periimplantitis Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Periodontal Res Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Periimplantitis Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Periodontal Res Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos