Your browser doesn't support javascript.
loading
Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse.
Xu, Feng; Sudo, Yusuke; Sanechika, Sho; Yamashita, Junpei; Shimaguchi, Sho; Honda, Shun-ichiro; Sumi-Ichinose, Chiho; Mori-Kojima, Masayo; Nakata, Rieko; Furuta, Tadaomi; Sakurai, Minoru; Sugimoto, Masahiro; Soga, Tomoyoshi; Kondo, Kazunao; Ichinose, Hiroshi.
Afiliación
  • Xu F; Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
  • Sudo Y; Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
  • Sanechika S; Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
  • Yamashita J; Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
  • Shimaguchi S; Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
  • Honda S; Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
  • Sumi-Ichinose C; Department of Pharmacology, School of Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
  • Mori-Kojima M; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan.
  • Nakata R; Department of Food Science and Nutrition, Nara Women's University, Nara 630-8506, Japan.
  • Furuta T; Center for Biological Resources and Informatics, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
  • Sakurai M; Center for Biological Resources and Informatics, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
  • Sugimoto M; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan.
  • Soga T; Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan.
  • Kondo K; Department of Pharmacology, School of Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
  • Ichinose H; Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan. Electronic address: hichinos@bio.titech.ac.jp.
FEBS Lett ; 588(21): 3924-31, 2014 Nov 03.
Article en En | MEDLINE | ID: mdl-25240194
Quinonoid dihydropteridine reductase (QDPR) catalyzes the regeneration of tetrahydrobiopterin (BH4), a cofactor for monoamine synthesis, phenylalanine hydroxylation and nitric oxide production. Here, we produced and analyzed a transgenic Qdpr(-/-) mouse model. Unexpectedly, the BH4 contents in the Qdpr(-/-) mice were not decreased and even increased in some tissues, whereas those of the oxidized form dihydrobiopterin (BH2) were significantly increased. We demonstrated that unlike the wild-type mice, dihydrofolate reductase regenerated BH4 from BH2 in the mutants. Furthermore, we revealed wide alterations in folate-associated metabolism in the Qdpr(-/-) mice, which suggests an interconnection between folate and biopterin metabolism in the transgenic mouse model.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidorreductasas / Biopterinas / Ácido Fólico Límite: Animals Idioma: En Revista: FEBS Lett Año: 2014 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidorreductasas / Biopterinas / Ácido Fólico Límite: Animals Idioma: En Revista: FEBS Lett Año: 2014 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido