Calcium signaling in pancreatic ß-cells in health and in Type 2 diabetes.
Cell Calcium
; 56(5): 340-61, 2014 Nov.
Article
en En
| MEDLINE
| ID: mdl-25239387
Changes in cytosolic free Ca(2+) concentration ([Ca(2+)]c) play a crucial role in the control of insulin secretion from the electrically excitable pancreatic ß-cell. Secretion is controlled by the finely tuned balance between Ca(2+) influx (mainly through voltage-dependent Ca(2+) channels, but also through voltage-independent Ca(2+) channels like store-operated channels) and efflux pathways. Changes in [Ca(2+)]c directly affect [Ca(2+)] in various organelles including the endoplasmic reticulum (ER), mitochondria, the Golgi apparatus, secretory granules and lysosomes, as imaged using recombinant targeted probes. Because most of these organelles have specific Ca(2+) influx and efflux pathways, they mutually influence free [Ca(2+)] in the others. In this article, we review the mechanisms of control of [Ca(2+)] in various compartments and particularly the cytosol, the endoplasmic reticulum ([Ca(2+)]ER), acidic stores and mitochondrial matrix ([Ca(2+)]mito), focusing chiefly on the most important physiological stimulus of ß-cells, glucose. We also briefly review some alterations of ß-cell Ca(2+) homeostasis in Type 2 diabetes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Calcio
/
Señalización del Calcio
/
Diabetes Mellitus Tipo 2
Límite:
Humans
Idioma:
En
Revista:
Cell Calcium
Año:
2014
Tipo del documento:
Article
Pais de publicación:
Países Bajos