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Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.
Mun, Bora; Wang, Weihong; Kim, Hiyoung; Hahn, Dongyup; Yang, Inho; Won, Dong Hwan; Kim, Eun-hee; Lee, Jihye; Han, Chulkyeong; Kim, Hyunji; Ekins, Merrick; Nam, Sang-Jip; Choi, Hyukjae; Kang, Heonjoong.
Afiliación
  • Mun B; Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul, 151-747, Republic of Korea.
Arch Pharm Res ; 38(1): 18-25, 2015 Jan.
Article en En | MEDLINE | ID: mdl-25231340
Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3ß-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3ß-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3ß,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poríferos / Esteroles / Colestadienoles / Colestenos / Noresteroides Límite: Animals / Humans Idioma: En Revista: Arch Pharm Res Año: 2015 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poríferos / Esteroles / Colestadienoles / Colestenos / Noresteroides Límite: Animals / Humans Idioma: En Revista: Arch Pharm Res Año: 2015 Tipo del documento: Article Pais de publicación: Corea del Sur