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Olfactory Pathology in Central Nervous System Demyelinating Diseases.
DeLuca, Gabriele C; Joseph, Albert; George, Jithin; Yates, Richard L; Hamard, Marie; Hofer, Monika; Esiri, Margaret M.
Afiliación
  • DeLuca GC; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Joseph A; Oxford Medical School, University of Oxford, Oxford, UK.
  • George J; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Yates RL; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Hamard M; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Hofer M; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.
  • Esiri MM; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Brain Pathol ; 25(5): 543-51, 2015 Sep.
Article en En | MEDLINE | ID: mdl-25230202
Olfactory dysfunction is common in multiple sclerosis (MS). Olfactory bulb and tract pathology in MS and other demyelinating diseases remain unexplored. A human autopsy cohort of pathologically confirmed cases encompassing the spectrum of demyelinating disease (MS; n = 17), neuromyelitis optica [(NMO); n = 3] and acute disseminated encephalomyelitis [(ADEM); n = 7] was compared to neuroinflammatory [herpes simplex virus encephalitis (HSE); n = 3], neurodegenerative [Alzheimer's disease (AD); n = 4] and non-neurologic (n = 8) controls. For each case, olfactory bulbs and/or tracts were stained for myelin, axons and inflammation. Inferior frontal cortex and hippocampus were stained for myelin in a subset of MS and ADEM cases. Olfactory bulb/tract demyelination was frequent in all demyelinating diseases [MS 12/17 (70.6%); ADEM 3/7 (42.9%); NMO 2/3 (66.7%)] but was absent in HSE, AD and non-neurologic controls. Inflammation was greater in the demyelinating diseases compared to non-neurologic controls. Olfactory bulb/tract axonal loss was most severe in MS where it correlated significantly with the extent of demyelination (r = 0.610, P = 0.009) and parenchymal inflammation (r = 0.681, P = 0.003). The extent of olfactory bulb/tract demyelination correlated with that found in the adjacent inferior frontal cortex but not hippocampus. We provide unequivocal evidence that olfactory bulb/tract demyelination is frequent, can occur early and is highly inflammatory, and is specific to demyelinating disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / Enfermedades Desmielinizantes Límite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Pathol Asunto de la revista: CEREBRO / PATOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bulbo Olfatorio / Enfermedades Desmielinizantes Límite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Pathol Asunto de la revista: CEREBRO / PATOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Suiza