Acne pathogenesis: history of concepts.
Dermatology
; 229(1): 1-46, 2014.
Article
en En
| MEDLINE
| ID: mdl-25228295
From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as mandatory. In the 1970s, the onset of isotretinoin dramatically improved acne management. It also provided great opportunities for a better understanding of the pathogenic factors of acne. This study analyzes their genesis and development from the seminal contributions until recent advances.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Propionibacterium acnes
/
Sebo
/
Infecciones por Bacterias Grampositivas
/
Enfermedades Cutáneas Bacterianas
/
Dermatitis Seborreica
/
Acné Vulgar
/
Inflamación
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Dermatology
Asunto de la revista:
DERMATOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Suiza