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Synthesis and biological assays on cancer cells of dinuclear gold complexes with novel functionalised di(N-heterocyclic carbene) ligands.
Baron, Marco; Bellemin-Laponnaz, Stéphane; Tubaro, Cristina; Basato, Marino; Bogialli, Sara; Dolmella, Alessandro.
Afiliación
  • Baron M; Dipartimento di Scienze Chimiche, Università degli Studi di Padova, via F. Marzolo 1, 35131 Padova, Italy.
  • Bellemin-Laponnaz S; Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), CNRS-Université de Strasbourg UMR7504, 23 rue du Loess BP 43, 67034 Strasbourg, France; University of Strasbourg, Institute for Advanced Study (USIAS), 5 allée du Général Rouvillois, 67083 Strasbourg, France. Electronic address: bel
  • Tubaro C; Dipartimento di Scienze Chimiche, Università degli Studi di Padova, via F. Marzolo 1, 35131 Padova, Italy. Electronic address: cristina.tubaro@unipd.it.
  • Basato M; Dipartimento di Scienze Chimiche, Università degli Studi di Padova, via F. Marzolo 1, 35131 Padova, Italy.
  • Bogialli S; Dipartimento di Scienze Chimiche, Università degli Studi di Padova, via F. Marzolo 1, 35131 Padova, Italy.
  • Dolmella A; Dipartimento di Scienze del Farmaco, Università degli Studi di Padova, via F. Marzolo 5, 35131 Padova, Italy.
J Inorg Biochem ; 141: 94-102, 2014 Dec.
Article en En | MEDLINE | ID: mdl-25226437
New dinuclear di(N-heterocyclic carbene) silver(I), gold(I) and gold(III) complexes have been synthesised and their antiproliferative effects towards various cancer cell lines have been screened. The di(N-heterocyclic carbene) ligands have a propylene linker between the carbene moieties and the imidazole backbone has been functionalised with a 1-benzyl- or 1-PEG-1,2,3-triazole ring (PEG=poly(ethylene glycol)) via a CuAAC (copper azido alkyne cycloaddition) reaction. The resulting gold(I) and gold(III) complexes display an antiproliferative activity superior to that of the unfunctionalised pristine complexes together with a higher selectivity towards cancerous cells with respect to healthy cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plata / Compuestos Orgánicos de Oro / Complejos de Coordinación / Metano / Antineoplásicos Límite: Humans Idioma: En Revista: J Inorg Biochem Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plata / Compuestos Orgánicos de Oro / Complejos de Coordinación / Metano / Antineoplásicos Límite: Humans Idioma: En Revista: J Inorg Biochem Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos