Frontal deficits differentiate progressive supranuclear palsy from Parkinson's disease.

Lee, Young-Eun C; Williams, David R; Anderson, Jacqueline F I

Lee, Young-Eun C; Williams, David R; Anderson, Jacqueline F I.

Afiliación

Lee YE; Melbourne School of Psychological Sciences, University of Melbourne, Victoria, Australia.
Williams DR; Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia.
Anderson JF; Van Cleef Roet Centre for Nervous Diseases, Monash University, Melbourne, Victoria, Australia.

J Neuropsychol ; 10(1): 1-14, 2016 Mar.

Article en En | MEDLINE | ID: mdl-25223526

RESUMEN

The clinical differentiation of progressive supranuclear palsy from Parkinson's disease can be challenging, due to overlapping clinical features and a lack of diagnostic markers. Abnormalities in cognitive function form part of the clinical spectrums of these diseases and distinctive cognitive profiles may be helpful in differentiating these diseases in the diagnostic period. A comprehensive neuropsychological test battery was administered to 12 patients with clinically diagnosed progressive supranuclear palsy and 12 patients with Parkinson's disease matched for age and disease duration. Effect size (Cohen's d) was calculated for cognitive tests that were significantly different between groups. Patients with progressive supranuclear palsy performed significantly worse than those with Parkinson's disease on measures of processing speed, verbal fluency, planning, verbal abstract reasoning, verbal memory, and made more perseverative responses on a set shifting task. Measures of executive function, manual dexterity and processing speed were most diagnostically useful (Cohen's d > 2.0) in differentiating between progressive supranuclear palsy and Parkinson's disease. These findings suggest that more severe and prominent 'frontal' cognitive deficits in patients with progressive parkinsonism would be helpful in predicting progressive supranuclear palsy rather than Parkinson's disease and these findings may contribute to the development of diagnostic criteria.

Asunto(s)

Cognición; Enfermedad de Parkinson/diagnóstico; Enfermedad de Parkinson/psicología; Parálisis Supranuclear Progresiva/diagnóstico; Parálisis Supranuclear Progresiva/psicología; Anciano; Estudios de Casos y Controles; Diagnóstico Diferencial; Femenino; Humanos; Masculino; Pruebas Neuropsicológicas

Palabras clave

Parkinson's disease; Parkinsonism; Richardson's syndrome; executive function; neuropsychology; progressive supranuclear palsy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Parálisis Supranuclear Progresiva / Cognición Tipo de estudio: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Neuropsychol Asunto de la revista: NEUROLOGIA / PSICOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido

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