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Comprehensive biomarker profiling in patients with obstructive sleep apnea.
Maeder, Micha T; Strobel, Werner; Christ, Michael; Todd, John; Estis, Joel; Wildi, Karin; Thalmann, Gregor; Hilti, Jonas; Brutsche, Martin; Twerenbold, Raphael; Rickli, Hans; Mueller, Christian.
Afiliación
  • Maeder MT; Division of Cardiology, University Hospital Basel, Switzerland; Division of Cardiology, Kantonsspital St. Gallen, Switzerland. Electronic address: micha.maeder@kssg.ch.
  • Strobel W; Division of Respiratory Medicine, University Hospital Basel, Switzerland.
  • Christ M; Division of Internal Medicine, University Hospital Basel, Switzerland; Department of Emergency and Critical Care Medicine, City Hospital Nuremberg, Germany.
  • Todd J; Singulex, Inc., Alameda, CA, USA.
  • Estis J; Singulex, Inc., Alameda, CA, USA.
  • Wildi K; Division of Cardiology, University Hospital Basel, Switzerland; Division of Internal Medicine, University Hospital Basel, Switzerland.
  • Thalmann G; Division of Cardiology, University Hospital Basel, Switzerland; Division of Internal Medicine, University Hospital Basel, Switzerland.
  • Hilti J; Division of Cardiology, University Hospital Basel, Switzerland; Division of Internal Medicine, University Hospital Basel, Switzerland.
  • Brutsche M; Division of Respiratory Medicine, University Hospital Basel, Switzerland; Division of Respiratory Medicine, Kantonsspital St. Gallen, Switzerland.
  • Twerenbold R; Division of Cardiology, University Hospital Basel, Switzerland; Division of Internal Medicine, University Hospital Basel, Switzerland.
  • Rickli H; Division of Cardiology, Kantonsspital St. Gallen, Switzerland.
  • Mueller C; Division of Cardiology, University Hospital Basel, Switzerland; Division of Internal Medicine, University Hospital Basel, Switzerland.
Clin Biochem ; 48(4-5): 340-6, 2015 Mar.
Article en En | MEDLINE | ID: mdl-25218814
OBJECTIVES: The pathophysiological links between obstructive sleep apnea syndrome (OSAS) and cardiovascular mortality are incompletely understood. We aimed to contribute to a better characterization by using comprehensive biomarker profiling quantifying hemodynamic cardiac stress, cardiomyocyte injury, inflammation, endothelial function, matrix turnover and metabolism. DESIGN AND METHODS: In 65 patients with moderate or severe OSAS [apnea-hypopnea index (AHI) 39±20/h] and 33 patients with no or mild OSAS (AHI 8+4/h), B-type natriuretic peptide (BNP), N-terminal-pro-BNP (NT-proBNP), high-sensitivity cardiac troponin I (hs-cTnI), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and insulin were measured before and after sleep. In a subgroup measurements were repeated in a second night with continuous positive airway pressure (CPAP). RESULTS: Patients with moderate/severe OSAS had higher insulin before sleep [median (interquartile range), 36.4 (21.9-52.1) vs. 20.8 (10.6-32.8)mU/mL; p=0.006], higher IL-6 after sleep [1.00 (0.73-1.58) vs. 0.72 (0.48-0.94)pg/mL; p=0.005], and larger relative overnight reduction in BNP [-9 (-35-0) vs. -3 (-21-13)%; p=0.04] than those with mild/no OSAS. Insulin before sleep was the only independent predictor of moderate/severe OSAS. Insulin before and IL-6 after sleep were independent predictors of severe OSAS, and when combined provided high diagnostic accuracy for severe OSAS (area under the receiver operator characteristic curve 0.80; 95%-confidence interval 0.69-0.91). In contrast, there were no significant differences in NT-proBNP, hs-cTnI, VEGF, and MMP-9 between moderate/severe and mild/no OSAS. Short-term CPAP had no impact on biomarker concentrations before and after sleep. CONCLUSIONS: Significant OSAS is characterized by a distinct biomarker profile including high insulin before and high IL-6 after sleep.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-6 / Apnea Obstructiva del Sueño / Insulina Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Biochem Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-6 / Apnea Obstructiva del Sueño / Insulina Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Biochem Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos