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Effects of low dose endosulfan exposure on brain neurotransmitter levels in the African clawed frog Xenopus laevis.
Preud'homme, Valérie; Milla, Sylvain; Gillardin, Virginie; De Pauw, Edwin; Denoël, Mathieu; Kestemont, Patrick.
Afiliación
  • Preud'homme V; Research Unit in Environmental and Evolutionary Biology, University of Namur, Belgium; Laboratory of Fish and Amphibian Ethology, Behavioural Biology Unit, Department of Biology, Ecology and Evolution, University of Liège, Belgium.
  • Milla S; Research Unit in Environmental and Evolutionary Biology, University of Namur, Belgium.
  • Gillardin V; Research Unit in Environmental and Evolutionary Biology, University of Namur, Belgium.
  • De Pauw E; Mass Spectrometry Laboratory, Department of Chemistry, GIGA, University of Liège, Belgium.
  • Denoël M; Laboratory of Fish and Amphibian Ethology, Behavioural Biology Unit, Department of Biology, Ecology and Evolution, University of Liège, Belgium.
  • Kestemont P; Research Unit in Environmental and Evolutionary Biology, University of Namur, Belgium. Electronic address: Patrick.kestemont@unamur.be.
Chemosphere ; 120: 357-64, 2015 Feb.
Article en En | MEDLINE | ID: mdl-25192837
Understanding the impact of pesticides in amphibians is of growing concern to assess the causes of their decline. Among pesticides, endosulfan belongs to one of the potential sources of danger because of its wide use and known effects, particularly neurotoxic, on a variety of organisms. However, the effect of endosulfan was not yet evaluated on amphibians at levels encompassing simultaneously brain neurotransmitters and behavioural endpoints. In this context, tadpoles of the African clawed frog Xenopus laevis were submitted to four treatments during 27 d: one control, one ethanol control, and two low environmental concentrations of endosulfan (0.1 and 1 µg L(-1)). Endosulfan induced a significant increase of brain serotonin level at both concentrations and a significant increase of brain dopamine and GABA levels at the lower exposure but acetylcholinesterase activity was not modified by the treatment. The gene coding for the GABA transporter 1 was up-regulated in endosulfan contaminated tadpoles while the expression of other genes coding for the neurotransmitter receptors or for the enzymes involved in their metabolic pathways was not significantly modified by endosulfan exposure. Endosulfan also affected foraging, and locomotion in links with the results of the physiological assays, but no effects were seen on growth. These results show that low environmental concentrations of endosulfan can induce adverse responses in X. laevis tadpoles. At a broader perspective, this suggests that more research using and linking multiple markers should be used to understand the complex mode of action of pollutants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Xenopus laevis / Encéfalo / Neurotransmisores / Endosulfano / Insecticidas Límite: Animals Idioma: En Revista: Chemosphere Año: 2015 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Xenopus laevis / Encéfalo / Neurotransmisores / Endosulfano / Insecticidas Límite: Animals Idioma: En Revista: Chemosphere Año: 2015 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido