Molecular mechanisms involved in the control of neurohypophyseal hormones secretion.

Iovino, M; Guastamacchia, E; Giagulli, V A; Licchelli, B; Iovino, E; Triggiani, V

Iovino, M; Guastamacchia, E; Giagulli, V A; Licchelli, B; Iovino, E; Triggiani, V.

Afiliación

Triggiani V; Interdisciplinary Department of Medicine-Endocrinology and Metabolic Diseases. University of Bari "Aldo Moro", Bari, Italy. micheleiovino06@libero.it.

Curr Pharm Des ; 20(42): 6702-13, 2014.

Article en En | MEDLINE | ID: mdl-25190061

RESUMEN

The regulation of neurohypophyseal peptides secretion reflects the convergence of a large number of afferent neural pathways on vasopressinergic and oxytocinergic neurons of supraoptic (SON) and paraventricular nuclei (PVN). In addition to afferent input, vasopressin and oxytocin can also exert an autocrine regulation of neuronal activity. In fact, magnocellular neurons (MCNs) of SON and PVN are able to secrete these hormones not only at the endings of their terminal axons, but also from their dendrites and this local release, by activating a range of ion gated, ion channel and G protein coupled receptors, participate in pre- and post-synaptic modulation of neural activity of MCNs. In this review we analyzed the molecular mechanisms involved in the control of neurohypophyseal hormones secretion and related possible pharmacological targets.

Asunto(s)

Hormonas Neurohipofisarias/metabolismo; Animales; Humanos; Neuronas/metabolismo; Oxitocina/metabolismo; Vasopresinas/metabolismo

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormonas Neurohipofisarias Límite: Animals / Humans Idioma: En Revista: Curr Pharm Des Asunto de la revista: FARMACIA Año: 2014 Tipo del documento: Article Pais de publicación: Emiratos Árabes Unidos

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links