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Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN.
Hafez Ghoran, Salar; Saeidnia, Soodabeh; Babaei, Esmaeil; Kiuchi, Fumiyuki; Dusek, Michal; Eigner, Vaclav; Dehno Khalaji, Aliakbar; Soltani, Alireza; Ebrahimi, Pouneh; Mighani, Hossein.
Afiliación
  • Hafez Ghoran S; Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran; Department of Chemistry, Faculty of Sciences, Golestan University, Gorgan 4913815759, Iran. Electronic address: S.Hafezghoran@gu.ac.ir.
  • Saeidnia S; Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran.
  • Babaei E; Department of Animal Biology, School of Natural Sciences, University of Tabriz, Tabriz, Iran.
  • Kiuchi F; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Keio University, Tokyo, Japan.
  • Dusek M; Institute of Physics AS CR, v.v.i., Na Slovance 2, 182 21 Prague 8, Czech Republic.
  • Eigner V; Institute of Physics AS CR, v.v.i., Na Slovance 2, 182 21 Prague 8, Czech Republic.
  • Dehno Khalaji A; Department of Chemistry, Faculty of Sciences, Golestan University, Gorgan 4913815759, Iran.
  • Soltani A; Department of Chemistry, Gorgan Branch, Islamic Azad University, Gorgan, Iran.
  • Ebrahimi P; Department of Chemistry, Faculty of Sciences, Golestan University, Gorgan 4913815759, Iran.
  • Mighani H; Department of Chemistry, Faculty of Sciences, Golestan University, Gorgan 4913815759, Iran.
Bioorg Chem ; 57: 51-56, 2014 Dec.
Article en En | MEDLINE | ID: mdl-25181677
In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3',4'-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a=11.7676 (2)Å, b=20.1174 (4)Å, c=7.8645 (9)Å, ß=93.544 (2)°, V=1858.23 (7)Å(3), monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Scilla / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Scilla / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos