Biological activities of interleukin-2 and gamma-interferon in bovine T lymphocyte conditioned media.
J Biol Regul Homeost Agents
; 3(4): 139-45, 1989.
Article
en En
| MEDLINE
| ID: mdl-2517811
Interleukin 2 and gamma-interferon were revealed in cultures of Concanavalin A-activated bovine mononuclear cells from peripheral blood leukocytes and their kinetics of production were described. Cyclosporin A could dramatically inhibit the synthesis of interleukin 2, whereas it did not affect the interleukin 2-dependent proliferation of bovine T blasts. Bovine T lymphocyte conditioned media (TLCM) containing gamma-interferon increased the expression of beta-2 microglobulin in human HEL (Human Embryo Lung) 299 cells and exerted a potent anti-proliferative effect upon bovine Aubek cells. The beta-2 microglobulin modulating activity of bovine gamma-interferon was exerted at very low concentrations, which showed no detectable antiviral activity on human cells.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucocitos Mononucleares
/
Microglobulina beta-2
/
Interferón gamma
/
Interleucina-2
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Biol Regul Homeost Agents
Asunto de la revista:
BIOLOGIA
/
BIOQUIMICA
Año:
1989
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Italia