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CT of the abdomen: degree and quality of enhancement obtained with two concentrations of the same iodinated contrast medium with fixed iodine delivery rate and total iodine load.
Paparo, Francesco; Garello, Isabella; Bacigalupo, Lorenzo; Marziano, Andrea; Galletto Pregliasco, Athena; Rollandi, Ludovica; Puppo, Cristina; Mattioli, Francesca; Puntoni, Matteo; Rollandi, Gian Andrea.
Afiliación
  • Paparo F; Radiology Unit, Diagnostic Imaging Department, E.O. Ospedali Galliera, Genoa, Italy.
  • Garello I; Radiology Unit, Diagnostic Imaging Department, E.O. Ospedali Galliera, Genoa, Italy.
  • Bacigalupo L; Radiology Unit, Diagnostic Imaging Department, E.O. Ospedali Galliera, Genoa, Italy.
  • Marziano A; Radiology Unit, Diagnostic Imaging Department, E.O. Ospedali Galliera, Genoa, Italy.
  • Galletto Pregliasco A; Radiology Unit, Diagnostic Imaging Department, E.O. Ospedali Galliera, Genoa, Italy.
  • Rollandi L; School of Medicine, University of Genoa, Genoa, Italy.
  • Puppo C; Radiology Unit, Diagnostic Imaging Department, E.O. Ospedali Galliera, Genoa, Italy.
  • Mattioli F; Pharmacology and Toxicology Unit, Internal Medicine Department, University of Genoa, Genoa, Italy.
  • Puntoni M; Biostatistics Unit, Office of the Scientific Director, Genoa, Italy.
  • Rollandi GA; Radiology Unit, Diagnostic Imaging Department, E.O. Ospedali Galliera, Genoa, Italy. Electronic address: rollandi@galliera.it.
Eur J Radiol ; 83(11): 1995-2000, 2014 Nov.
Article en En | MEDLINE | ID: mdl-25174776
OBJECTIVES: to compare vascular and parenchymal enhancement in abdominal computed tomography (CT) using two iodine concentrations (370 vs 300mgI/mL) of the same contrast medium (CM) molecule (iopromide), using fixed iodine delivery rate (IDR, 1.2gI/s) and total iodine load (630mgI/kg). METHODS: 144 patients were randomized into two groups: group A receiving iopromide 370 and group B receiving iopromide 300. Attenuation values (AV) were measured in correspondence to key anatomical structures on different phases and compared between groups with parametrical tests. Qualitative analysis was also performed. Peak injection pressure and local discomfort at the site of injection (pain and warmth) were registered. RESULTS: mean AV of abdominal aorta in late arterial phase were 300.32±59.76 for group A and 298.2±59.14 for group B (p=0.8); mean AV of portal vein in portal phase were 190.5±29.92 for group A and 192.91±24.12 for group B (p=0.6). Mean AV of liver parenchyma in portal phase were 124.73±18.22 for group A and 125.11±15.7 for group B (p=0.9); mean AV of liver at equilibrium were 85.11±7.75 for group A and 85.41±8.09 for group B (p=0.8). Qualitative analysis did not show significant differences between groups (p>0.05). Median peak injection pressure was lower in group B (93psi, 76-172) than in group A (115psi, 88-288, p<0.0001), while discomfort at injection site was not significantly different (p>0.05). CONCLUSIONS: with fixed IDR and total iodine load, comparable quantitative and qualitative enhancement can be achieved with different concentrations of the same CM. Peak injection pressure increases using CM with higher iodine concentration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aorta Abdominal / Vena Porta / Tomografía Computarizada por Rayos X / Medios de Contraste / Yodo / Hígado Tipo de estudio: Clinical_trials / Observational_studies / Qualitative_research Límite: Aged / Female / Humans / Male Idioma: En Revista: Eur J Radiol Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aorta Abdominal / Vena Porta / Tomografía Computarizada por Rayos X / Medios de Contraste / Yodo / Hígado Tipo de estudio: Clinical_trials / Observational_studies / Qualitative_research Límite: Aged / Female / Humans / Male Idioma: En Revista: Eur J Radiol Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Irlanda